The　clinical　treatment　of　infected　skin　injuries　caused　by　exogenous　bacteria　faces　great　challenges.　Conventional　therapeutic　approaches　are　difficult　to　achieve　synergistic　effects　of　infection　control　and　induction　of　skin　regeneration.　In　this　study,　a　novel　tannic　acid-based　physically　cross-linked　double　network　hydrogel　(PDH　gel)　was　prepared　on　demand　by　covalent　cross-linking　of　tannic　acid　(TA)　with　polyvinyl　alcohol　(PVA)　and　chelating　ligand　of　TA　with　Fe3+.　The　homogeneity　of　the　hydrogel　was　achieved　by　the　action　of　glycol　dispersant.　With　the　anti-inflammatory　and　antioxidant　properties　of　Fe3+　and　TA,　this　hydrogel　exhibited　excellent　antibacterial　properties　by　achieving　99.69%　and　99.36%　bacterial　inhibition　against　E.coli　and　S.　aureus,　respectively.　Moreover,　the　PDH　gel　exhibits　good　biocompatibility,　stretchability　(up　to　200%)　and　skin-friendliness.　After　14　days　of　PDH-1　gel　implantation　in　a　rat　model　infected　by　S.　aureus,　the　wound　healing　rate　was　as　high　as　95.21%.　PDH　gel-1　showed　more　granulation　tissue,　more　pronounced　blood　vessels,　higher　collagen　fiber　density　and　good　collagen　deposition,　and　its　recovery　effect　was　better　than　that　of　PSH　gel　and　PDH　gel-2　in　vivo.　Hence,　this　study　provides　a　novel　avenue　for　the　design　of　future　clinical　infected　wound　healing　dressings.　©　2023　Elsevier　B.V.