The　unique　biodegradation　and　mineralization　properties　of　nanosized　CO32−-　containing　hydroxyapatite　(HCA)-coated　BBG　(nano-HCA@BG)　make　it　a　promising　material　for　soft　tissue　repair.　However,　its　single-function　solid　powder　form　makes　it　difficult　to　control　drug　release　rates,　limiting　its　potential　in　vivo　application.　To　address　this　challenge,　we　designed　a　hierarchical　multifunctional　composite　by　incorporating　gelatin　with　nano-HCA@BG　loaded　with　AgNPs.　The　hierarchical　composite　achieved　a　high　degree　of　structural　fit　from　nanometer　to　micrometer　scale,　as　demonstrated　by　structural　characterization　results.　The　composite　showed　improved　encapsulation　of　nanodrug　and　controlled　degradation,　as　confirmed　by　degradation　and　antimicrobial　property　results.　Wound　healing　experiments　in　vivo　revealed　efficient　encapsulation　of　nano-HCA@BG　through　specific　combination　of　gelatin　and　nano-HCA@BG,　leading　to　improved　controlled　degradation　and　biological　activity　of　the　glass.　The　study　also　developed　a　dynamic　flowing　drug　loading　method　that　integrated　material　preparation　and　drug　loading,　thus　improving　the　efficiency　of　drug　loading　of　the　nano-HCA@BG.　Overall,　our　study　demonstrates　a　new　method　for　the　preparation　of　hierarchical　functional　biomaterials　of　bioglass,　laying　the　foundation　for　nano-HCA@BG　to　play　an　important　role　in　tissue　repair.　Moreover,　our　findings　suggest　that　better　understanding　of　the　structure　and　biological　properties　of　nano-HCA@BG　could　expand　its　application　in　other　biomedical　fields　such　as　drug　delivery.　©　2023　Elsevier　Ltd　and　Techna　Group　S.r.l.