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author:

Tan, Renhao (Tan, Renhao.) [1] | Chen, Ruiguo (Chen, Ruiguo.) [2] | Sun, Lei (Sun, Lei.) [3] | Xu, Shuai (Xu, Shuai.) [4] | Ji, Zhibo (Ji, Zhibo.) [5] | Ji, Sihan (Ji, Sihan.) [6] | Liu, Chao (Liu, Chao.) [7] | Zhao, Xianglong (Zhao, Xianglong.) [8] | Xu, Huangtao (Xu, Huangtao.) [9] | Xia, Haining (Xia, Haining.) [10] | Wang, Yujuan (Wang, Yujuan.) [11] | Wang, Junfeng (Wang, Junfeng.) [12] | Ma, Kun (Ma, Kun.) [13]

Indexed by:

EI Scopus SCIE

Abstract:

The unique biodegradation and mineralization properties of nanosized CO32-- containing hydroxyapatite (HCA)-coated BBG (nano-HCA@BG) make it a promising material for soft tissue repair. However, its single-function solid powder form makes it difficult to control drug release rates, limiting its potential in vivo application. To address this challenge, we designed a hierarchical multifunctional composite by incorporating gelatin with nano-HCA@BG loaded with AgNPs. The hierarchical composite achieved a high degree of structural fit from nano-meter to micrometer scale, as demonstrated by structural characterization results. The composite showed improved encapsulation of nanodrug and controlled degradation, as confirmed by degradation and antimicrobial property results. Wound healing experiments in vivo revealed efficient encapsulation of nano-HCA@BG through specific combination of gelatin and nano-HCA@BG, leading to improved controlled degradation and biological activity of the glass. The study also developed a dynamic flowing drug loading method that integrated material preparation and drug loading, thus improving the efficiency of drug loading of the nano-HCA@BG. Overall, our study demonstrates a new method for the preparation of hierarchical functional biomaterials of bioglass, laying the foundation for nano-HCA@BG to play an important role in tissue repair. Moreover, our findings suggest that better understanding of the structure and biological properties of nano-HCA@BG could expand its application in other biomedical fields such as drug delivery.

Keyword:

AgNPs/nano-HCA@BG/Gelatin Bacteriostatic Drug loading Hierarchical multifunctional composite Specific binding Wound healing

Community:

  • [ 1 ] [Tan, Renhao]Anhui Univ, Inst Phys Sci & Informat Technol, Hefei 230601, Peoples R China
  • [ 2 ] [Wang, Yujuan]Anhui Univ, Inst Phys Sci & Informat Technol, Hefei 230601, Peoples R China
  • [ 3 ] [Wang, Junfeng]Anhui Univ, Inst Phys Sci & Informat Technol, Hefei 230601, Peoples R China
  • [ 4 ] [Tan, Renhao]Chinese Acad Sci, Hefei Inst Phys Sci, High Magnet Field Lab, CAS Key Lab High Magnet Field & Ion Beam Phys Biol, Hefei 230031, Anhui, Peoples R China
  • [ 5 ] [Chen, Ruiguo]Chinese Acad Sci, Hefei Inst Phys Sci, High Magnet Field Lab, CAS Key Lab High Magnet Field & Ion Beam Phys Biol, Hefei 230031, Anhui, Peoples R China
  • [ 6 ] [Xu, Shuai]Chinese Acad Sci, Hefei Inst Phys Sci, High Magnet Field Lab, CAS Key Lab High Magnet Field & Ion Beam Phys Biol, Hefei 230031, Anhui, Peoples R China
  • [ 7 ] [Zhao, Xianglong]Chinese Acad Sci, Hefei Inst Phys Sci, High Magnet Field Lab, CAS Key Lab High Magnet Field & Ion Beam Phys Biol, Hefei 230031, Anhui, Peoples R China
  • [ 8 ] [Xu, Huangtao]Chinese Acad Sci, Hefei Inst Phys Sci, High Magnet Field Lab, CAS Key Lab High Magnet Field & Ion Beam Phys Biol, Hefei 230031, Anhui, Peoples R China
  • [ 9 ] [Xia, Haining]Chinese Acad Sci, Hefei Inst Phys Sci, High Magnet Field Lab, CAS Key Lab High Magnet Field & Ion Beam Phys Biol, Hefei 230031, Anhui, Peoples R China
  • [ 10 ] [Wang, Yujuan]Chinese Acad Sci, Hefei Inst Phys Sci, High Magnet Field Lab, CAS Key Lab High Magnet Field & Ion Beam Phys Biol, Hefei 230031, Anhui, Peoples R China
  • [ 11 ] [Wang, Junfeng]Chinese Acad Sci, Hefei Inst Phys Sci, High Magnet Field Lab, CAS Key Lab High Magnet Field & Ion Beam Phys Biol, Hefei 230031, Anhui, Peoples R China
  • [ 12 ] [Ma, Kun]Chinese Acad Sci, Hefei Inst Phys Sci, High Magnet Field Lab, CAS Key Lab High Magnet Field & Ion Beam Phys Biol, Hefei 230031, Anhui, Peoples R China
  • [ 13 ] [Chen, Ruiguo]Fuzhou Univ, Coll Mat Sci & Engn, Fuzhou 350108, Fujian, Peoples R China
  • [ 14 ] [Chen, Ruiguo]Anhui Med Univ, Affiliated Hosp 2, Dept Stomatol, Hefei, Anhui, Peoples R China
  • [ 15 ] [Sun, Lei]Anhui Med Univ, Affiliated Hosp 2, Dept Stomatol, Hefei, Anhui, Peoples R China
  • [ 16 ] [Ji, Zhibo]Anhui Med Univ, Affiliated Hosp 2, Dept Stomatol, Hefei, Anhui, Peoples R China
  • [ 17 ] [Ji, Sihan]Chinese Acad Sci, Inst Solid State Phys, Hefei Inst Phys Sci, Key Lab Mat Phys, Hefei 230031, Peoples R China
  • [ 18 ] [Ji, Sihan]Chinese Acad Sci, Hefei Inst Phys Sci, Inst Solid State Phys, Anhui Key Lab Nanomat & Nanotechnol, Hefei 230031, Peoples R China
  • [ 19 ] [Ji, Sihan]Univ Sci & Technol China, Hefei 230026, Peoples R China
  • [ 20 ] [Liu, Chao]Univ Sci & Technol China, Hefei 230026, Peoples R China
  • [ 21 ] [Zhao, Xianglong]Univ Sci & Technol China, Hefei 230026, Peoples R China
  • [ 22 ] [Xia, Haining]Univ Sci & Technol China, Hefei 230026, Peoples R China
  • [ 23 ] [Wang, Junfeng]Univ Sci & Technol China, Hefei 230026, Peoples R China
  • [ 24 ] [Liu, Chao]Chinese Acad Sci, Hefei Inst Phys Sci, Inst Intelligent Machines, Hefei 230031, Anhui, Peoples R China

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Source :

CERAMICS INTERNATIONAL

ISSN: 0272-8842

Year: 2023

Issue: 15

Volume: 49

Page: 25908-25919

5 . 1

JCR@2023

5 . 1 0 0

JCR@2023

JCR Journal Grade:1

CAS Journal Grade:1

Cited Count:

WoS CC Cited Count:

SCOPUS Cited Count:

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 1

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