Manufacturing　heteronanostructures　with　specific　physicochemical　characteristics　and　tightly　controllable　designs　is　very　appealing.　Herein,　we　reported　NIR-II　light-driven　dual　plasmonic　(AuNR-SiO2-Cu7S4)　antimicrobial　nanomotors　with　an　intended　Janus　configuration　through　the　overgrowth　of　copper-rich　Cu7S4　nanocrystals　at　only　one　high-curvature　site　of　Au　nanorods　(Au　NRs).　These　nanomotors　were　applied　for　photoacoustic　imaging　(PAI)-guided　synergistic　photothermal　and　photocatalytic　treatment　of　bacterial　infections.　Both　the　photothermal　performance　and　photocatalytic　activity　of　the　nanomotors　are　dramatically　improved　owing　to　the　strong　plasmon　coupling　between　Au　NRs　and　the　Cu7S4　component　and　enhanced　energy　transfer.　The　motion　behavior　of　nanomotors　promotes　transdermal　penetration　and　enhances　the　matter-bacteria　interaction.　More　importantly,　the　directional　navigation　and　synergistic　antimicrobial　activity　of　the　nanomotors　could　be　synchronously　driven　by　NIR-II　light.　The　marriage　of　active　motion　and　enhanced　antibacterial　activity　resulted　in　the　expected　good　antibacterial　effects　in　an　abscess　infection　mouse　model.　©　2023　American　Chemical　Society.