Objective:　Using　meta-analysis,　we　evaluate　circulating　tumor　cells(CTCs)　as　a　potential　diagnostic　tool　for　breast　cancer.Methods　A　document　search　was　conducted　using　publicly　available　databases　up　to　May　2021.　Specific　inclusion　and　exclusion　criteria　were　formulated　and　summarize　relevant　data　through　literature　types,　research　types,　case　populations,　samples,　etc.　Subgroup　analysis　of　documents　based　on　regions,　enrichment　methods,　and　detection　methods.　The　included　research　projects　were　evaluated　using　DeeKs＇　bias,　and　evaluation　indicators　such　as　specificity　(SPE),　sensitivity　(SEN),　diagnosis　odds　ratio　(DOR)　were　used　as　evaluation　indicators.Results:　16　studies　on　the　use　of　circulating　tumor　cells　to　diagnose　breast　cancer　were　included　in　our　meta-analysis.　Overall　sensitivity　value　was　0.50　(95%CI:0.48-0.52),　specificity　value　was　0.93　(95%CI:0.92-　0.95),　DOR　value　was　33.41　(95%CI:12.47-89.51),　and　AUC　value　was　0.8129.Conclusion:bIn　meta-regressions　and　subgroup　analysis,　potential　heterogeneity　factors　were　analyzed,　but　the　source　of　heterogeneity　is　still　unclear.　CTCs,　as　a　novel　tumor　marker,　have　a　good　diagnostic　value,　but　its　enrichment　and　detection　methods　still　need　to　continue　to　be　developed　to　improve　detection　accuracy.　Therefore,　CTCs　can　be　used　as　an　auxiliary　means　of　early　detection,　which　is　helpful　to　the　diagnosis　and　screening　of　breast　cancer.