Bisdemethoxycurcumin　(BDMC)　is　the　main　active　ingredient　that　is　isolated　from　Zingiberaceae　plants,　wherein　it　has　excellent　anti-tumor　effects.　However,　insolubility　in　water　limits　its　clinical　application.　Herein,　we　reported　a　microfluidic　chip　device　that　can　load　BDMC　into　the　lipid　bilayer　to　form　BDMC　thermosensitive　liposome　(BDMC　TSL).　The　natural　active　ingredient　glycyrrhizin　was　selected　as　the　surfactant　to　improve　solubility　of　BDMC.　Particles　of　BDMC　TSL　had　small　size,　homogenous　size　distribution,　and　enhanced　cultimulative　release　in　vitro.　The　anti-tumor　effect　of　BDMC　TSL　on　human　hepatocellular　carcinomas　was　investigated　via　3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium　bromide　method,　live/dead　staining,　and　flowcytometry.　These　results　showed　that　the　formulated　liposome　had　a　strong　cancer　cell　inhibitory,　and　presented　a　dose-dependent　inhibitory　effect　on　migration.　Further　mechanistic　studies　showed　that　BDMC　TSL　combined　with　mild　local　hyperthermia　could　significantly　upregulate　B　cell　lymphoma　2　associated　X　protein　levels　and　decrease　B　cell　lymphoma　2　protein　levels,　thereby　inducing　cell　apoptosis.　The　BDMC　TSL　that　was　fabricated　via　microfluidic　device　were　decomposed　under　mild　local　hyperthermia,　which　could　beneficially　enhance　the　anti-tumor　effect　of　raw　insoluble　materials　and　promote　translation　of　liposome.