Instant　rice　with　added　coarse　grain　(IR/CG)　is　a　new　type　of　coarse　grain　product　which　is　self-heating　and　convenient　to　eat　and　has　the　nutritional　value　of　coarse　grains.　However,　its　health　effects　are　not　clear　yet.　Therefore,　in　this　study,　the　effect　of　IR/CG　on　glucose　and　lipid　metabolism　was　explored　in　mice　with　type　2　diabetes　mellitus　(T2DM)　induced　by　high　fat　diet　(HFD)　combined　with　intraperitoneal　injection　of　streptozotocin.　The　mice　were　fed　on　HFD　alone　(model),　its　mixture　with　IR/CG　in　different　ratios:　25%　(low-dose　IR/CG,　IR/CG-L),　50%　(medium-dose　IR/CG,　IR/CG-M),　and　75%　(high-dose　IR/CG,　IR/CG-H),　IR/CG　alone,　or　a　basal　diet　(control).　During　the　dietary　intervention,　the　body　mass,　fasting　blood　glucose,　food　intake　and　glucose　tolerance　of　the　mice　were　measured.　After　the　IR/CG　intervention　for　four　weeks,　the　organ　coefficients　were　calculated,　and　the　pathological　changes　in　liver　and　pancreas　tissues　were　examined　by　hematoxylin　and　eosin　(HE)　staining.　Fasting　insulin　levels,　blood　glucose　and　lipid　levels,　and　proinflammatory　cytokines　levels　were　determined.　The　experimental　results　showed　that　dietary　supplementation　of　IR/CG　improved　blood　glucose　and　lipid　levels　in　T2DM　mice　to　different　extents,　and　this　effect　was　more　prominent　in　the　IR/CG-H　and　IR/CG　groups.　In　addition,　IR/CG-H　and　IR/CG　significantly　mitigated　insulin　resistance,　decreased　insulin　secretion,　glucagon　and　HbA1c　levels,　and　reduced　oxidative　stress　injury　and　inflammatory　cytokine　levels　in　T2DM　mice.　By　analyzing　the　organ　index　and　pathological　sections　of　liver　and　pancreas　tissues,　it　was　found　that　IR/CG　intervention　could　effectively　alleviate　liver　steatosis　and　partially　restore　the　structure　of　the　pancreatic　islets　in　mice.　Therefore,　the　substitution　of　high-fat　diet　by　IR/CG　has　a　significant　effect　on　regulating　blood　glucose　and　lipids　in　T2DM　mice,　which　can　provide　a　theoretical　basis　for　the　development　of　self-heating　rice　products　and　functional　foods　with　coarse-grain.　©　2023　Chinese　Chamber　of　Commerce.　All　rights　reserved.