MXene　materials　are　regarded　as　versatile　catalysts　for　multi-energy　utilization,　however,　designing　a　single　system　for　multiple　energy　harvesting　applications　is　challenging.　Here,　the　authors　theoretically　and　experimentally　validate　the　utilization　of　multiple　energy　sources　by　MXene　materials.　The　synchronous　harvesting　and　conversion　of　multiple　renewable　energy　sources　for　chemical　fuel　production　and　environmental　remediation　in　a　single　system　is　a　holy　grail　in　sustainable　energy　technologies.　However,　it　is　challenging　to　develop　advanced　energy　harvesters　that　satisfy　different　working　mechanisms.　Here,　we　theoretically　and　experimentally　disclose　the　use　of　MXene　materials　as　versatile　catalysts　for　multi-energy　utilization.　Ti3C2TX　MXene　shows　remarkable　catalytic　performance　for　organic　pollutant　decomposition　and　H-2　production.　It　outperforms　most　reported　catalysts　under　the　stimulation　of　light,　thermal,　and　mechanical　energy.　Moreover,　the　synergistic　effects　of　piezo-thermal　and　piezo-photothermal　catalysis　further　improve　the　performance　when　using　Ti3C2TX.　A　mechanistic　study　reveals　that　hydroxyl　and　superoxide　radicals　are　produced　on　the　Ti3C2TX　under　diverse　energy　stimulation.　Furthermore,　similar　multi-functionality　is　realized　in　Ti2CTX,　V2CTX,　and　Nb2CTX　MXene　materials.　This　work　is　anticipated　to　open　a　new　avenue　for　multisource　renewable　energy　harvesting　using　MXene　materials.