Background:　There　are　some　cases　of　Klippel-Feil　syndrome　with　spinal　cord　injury　in　clinical　work.　However,　there　is　no　literature　report　on　Brown-Sequard　syndrome　after　trauma.　We　report　a　case　of　Brown-Sequard　syndrome　following　minor　trauma　in　a　patient　with　KFS　type　III.　Her　Brown-Sequard　syndrome　is　caused　by　Klippel-Feil　syndrome.　Case　presentation:　We　found　a　38-year-old　female　patient　with　KFS　in　our　clinical　work.　She　was　unconscious　on　the　spot　following　a　minor　traumatic　episode.　After　treatment,　her　whole　body　was　numb　and　limb　activity　was　limited.　Half　an　hour　later,　she　felt　numb　and　weak　in　the　right　limb　and　weak　in　the　left　limb.　She　had　no　previous　hypertension,　diabetes,　or　coronary　heart　disease.　After　one-month　treatment　of　medication,　hyperbaric　oxygen,　rehabilitation,　and　acupuncture　in　our　hospital,　her　muscle　strength　partially　recovered,　but　the　treatment　effect　was　still　not　satisfactory.　Then,　she　underwent　surgical　treatment　and　postoperative　comprehensive　treatment,　and　rehabilitation　training.　She　was　able　to　take　care　of　herself　with　assistance,　and　her　condition　improved　from　grade　B　to　grade　D　according　to　the　ASIA　(ASIA　Impairment　Scale)　classification.　Conclusion:　KFS,　also　known　as　short　neck　deformity,　is　a　kind　of　congenital　deformity　characterized　by　impaired　formation　and　faulty　segmentation　of　the　cervical　spine,　often　associated　with　abnormalities　of　other　organs.　The　cervical　deformity　in　patients　with　KFS　can　alter　the　overall　mechanical　activity　of　the　spine,　as　well　as　the　compensatory　properties　of　the　spine　for　decelerating　and　rotatory　forces,　thus　increasing　the　chance　of　spinal　cord　injury　(SCI)　following　trauma.　Many　mechanisms　can　make　patients　more　susceptible　to　injury.　Increased　range　of　motion　of　the　segment　adjacent　to　the　fused　vertebral　body　may　lead　to　slippage　of　the　adjacent　vertebral　body　and　altered　disc　stress,　as　well　as　cervical　instability.　SCI　can　result　in　complete　or　incomplete　impairment　of　motor,　sensory　and　autonomic　nervous　functions　below　the　level　of　lesion.　This　woman　presented　with　symptoms　of　BSS,　a　rare　neurological　disorder　with　incomplete　SCI.　Judging　from　the　woman’s　symptoms,　we　concluded　that　previously　she　had　KFS,　which　resulted　in　SCI　without　fracture　and　dislocation　following　minor　trauma,　with　partial　BSS.　After　the　comprehensive　treatment　of　surgery,　hyperbaric　oxygen,　rehabilitation　therapy,　and　neurotrophic　drugs,　two　years　later,　we　found　her　symptoms　significantly　improved,　with　ASIA　Impairment　Scale　from　grade　B　to　grade　D,　and　her　ability　to　perform　activities　of　daily　living　with　aids.　©　2023,　BioMed　Central　Ltd.,　part　of　Springer　Nature.