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author:

Cheng, Meiqi (Cheng, Meiqi.) [1] | Hu, Le (Hu, Le.) [2] | Xu, Gan (Xu, Gan.) [3] | Pan, Panpan (Pan, Panpan.) [4] | Liu, Qing (Liu, Qing.) [5] | Zhang, Ziyue (Zhang, Ziyue.) [6] | He, Zhanpeng (He, Zhanpeng.) [7] | Wang, Chunxiao (Wang, Chunxiao.) [8] | Liu, Man (Liu, Man.) [9] | Chen, Li (Chen, Li.) [10] (Scholars:陈立) | Chen, Jingdi (Chen, Jingdi.) [11]

Indexed by:

EI Scopus SCIE

Abstract:

The clinical treatment of infected skin injuries caused by exogenous bacteria faces great challenges. Conventional therapeutic approaches are difficult to achieve synergistic effects of infection control and induction of skin regeneration. In this study, a novel tannic acid-based physically cross-linked double network hydrogel (PDH gel) was prepared on demand by covalent cross-linking of tannic acid (TA) with polyvinyl alcohol (PVA) and chelating ligand of TA with Fe3+. The homogeneity of the hydrogel was achieved by the action of glycol dispersant. With the anti-inflammatory and antioxidant properties of Fe3+ and TA, this hydrogel exhibited excellent antibacterial properties by achieving 99.69% and 99.36% bacterial inhibition against E.coli and S. aureus, respectively. Moreover, the PDH gel exhibits good biocompatibility, stretchability (up to 200%) and skin-friendliness. After 14 days of PDH-1 gel implantation in a rat model infected by S. aureus, the wound healing rate was as high as 95.21%. PDH gel-1 showed more granulation tissue, more pronounced blood vessels, higher collagen fiber density and good collagen deposition, and its recovery effect was better than that of PSH gel and PDH gel-2 in vivo. Hence, this study provides a novel avenue for the design of future clinical infected wound healing dressings.

Keyword:

Double network Fe 3+chelation Homogeneous hydrogel Infected wound healing Tannic acid

Community:

  • [ 1 ] [Cheng, Meiqi]Shandong Univ, Marine Coll, Weihai 264209, Peoples R China
  • [ 2 ] [Hu, Le]Shandong Univ, Marine Coll, Weihai 264209, Peoples R China
  • [ 3 ] [Pan, Panpan]Shandong Univ, Marine Coll, Weihai 264209, Peoples R China
  • [ 4 ] [Liu, Qing]Shandong Univ, Marine Coll, Weihai 264209, Peoples R China
  • [ 5 ] [Zhang, Ziyue]Shandong Univ, Marine Coll, Weihai 264209, Peoples R China
  • [ 6 ] [He, Zhanpeng]Shandong Univ, Marine Coll, Weihai 264209, Peoples R China
  • [ 7 ] [Wang, Chunxiao]Shandong Univ, Marine Coll, Weihai 264209, Peoples R China
  • [ 8 ] [Liu, Man]Shandong Univ, Marine Coll, Weihai 264209, Peoples R China
  • [ 9 ] [Chen, Jingdi]Shandong Univ, Marine Coll, Weihai 264209, Peoples R China
  • [ 10 ] [Pan, Panpan]Hubei Prov Key Lab Oral & Maxillofacial Dev & Rege, Wuhan 430022, Peoples R China
  • [ 11 ] [Xu, Gan]Fuzhou Univ, Coll Biol Sci & Technol, Fuzhou 350108, Peoples R China
  • [ 12 ] [Chen, Li]Fuzhou Univ, Coll Biol Sci & Technol, Fuzhou 350108, Peoples R China

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Source :

COLLOIDS AND SURFACES B-BIOINTERFACES

ISSN: 0927-7765

Year: 2023

Volume: 227

5 . 4

JCR@2023

5 . 4 0 0

JCR@2023

JCR Journal Grade:1

CAS Journal Grade:1

Cited Count:

WoS CC Cited Count: 6

SCOPUS Cited Count: 6

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 1

Online/Total:107/10011712
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