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author:

Wu, Peifen (Wu, Peifen.) [1] | Yang, Jie (Yang, Jie.) [2] | Chen, Chi (Chen, Chi.) [3] | Li, Ruili (Li, Ruili.) [4] | Chen, Shunxian (Chen, Shunxian.) [5] | Weng, Yanlin (Weng, Yanlin.) [6] | Lin, Yayi (Lin, Yayi.) [7] | Chen, Zhiying (Chen, Zhiying.) [8] | Yu, Fengfan (Yu, Fengfan.) [9] | Lu, Xucong (Lu, Xucong.) [10] (Scholars:吕旭聪) | Ni, Li (Ni, Li.) [11] (Scholars:倪莉) | Han, Jinzhi (Han, Jinzhi.) [12] (Scholars:韩金志)

Indexed by:

EI Scopus SCIE

Abstract:

Infections caused by pathogens can be a significant challenge in wound healing, particularly when antimicrobial resistance is a factor. This can pose a serious threat to human health and well-being. In this scenario, it is imperative to explore novel antimicrobial agents to fight against multi-drug resistant (MDR) pathogenic bacteria. This study employed rational design strategies, including truncation, amino acid replacement, and heterozygosity, to obtain seven a-helical, cationic, and engineered peptides based on the original template of Abhisin. Among the analogs of Abhisin, AB7 displayed broad-spectrum and potent antimicrobial activity, superior targeting of membranes and DNA, and the ability to disrupt biofilms and anti-endotoxins in vitro. Additionally, we evaluated the anti-infection ability of AB7 using a murine skin wound model infected with methicillin-resistant Staphylococcus aureus (MRSA) and found that AB7 displayed negligible toxicity both in vitro and in vivo. Furthermore, AB7 exhibited desirable therapeutic efficacy by reducing bacterial burden and pro-inflammatory mediators, modulating cytokines, promoting wound healing, and enhancing angiogenesis. These results highlight the potential of AB7 as a promising candidate for a new antibiotic.

Keyword:

Abhisin-like peptides Antimicrobial activity Arginine-rich peptides MRSA infections Murine wound model

Community:

  • [ 1 ] [Wu, Peifen]Fuzhou Univ, Inst Food Sci & Technol, Coll Biol Sci & Engn, Fuzhou 350108, Peoples R China
  • [ 2 ] [Yang, Jie]Fuzhou Univ, Inst Food Sci & Technol, Coll Biol Sci & Engn, Fuzhou 350108, Peoples R China
  • [ 3 ] [Chen, Shunxian]Fuzhou Univ, Inst Food Sci & Technol, Coll Biol Sci & Engn, Fuzhou 350108, Peoples R China
  • [ 4 ] [Weng, Yanlin]Fuzhou Univ, Inst Food Sci & Technol, Coll Biol Sci & Engn, Fuzhou 350108, Peoples R China
  • [ 5 ] [Lin, Yayi]Fuzhou Univ, Inst Food Sci & Technol, Coll Biol Sci & Engn, Fuzhou 350108, Peoples R China
  • [ 6 ] [Chen, Zhiying]Fuzhou Univ, Inst Food Sci & Technol, Coll Biol Sci & Engn, Fuzhou 350108, Peoples R China
  • [ 7 ] [Yu, Fengfan]Fuzhou Univ, Inst Food Sci & Technol, Coll Biol Sci & Engn, Fuzhou 350108, Peoples R China
  • [ 8 ] [Lu, Xucong]Fuzhou Univ, Inst Food Sci & Technol, Coll Biol Sci & Engn, Fuzhou 350108, Peoples R China
  • [ 9 ] [Ni, Li]Fuzhou Univ, Inst Food Sci & Technol, Coll Biol Sci & Engn, Fuzhou 350108, Peoples R China
  • [ 10 ] [Han, Jinzhi]Fuzhou Univ, Inst Food Sci & Technol, Coll Biol Sci & Engn, Fuzhou 350108, Peoples R China
  • [ 11 ] [Chen, Chi]Fujian Vocat Coll Agr, Coll Modern Agr Engn, Fuzhou 350302, Peoples R China
  • [ 12 ] [Li, Ruili]Nanjing Agr Univ, Coll Food Sci & Technol, Key Lab Food Proc & Qual Control, Minist Agr China, Nanjing 210095, Peoples R China

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Source :

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

ISSN: 0175-7598

Year: 2023

Issue: 21

Volume: 107

Page: 6621-6640

3 . 9

JCR@2023

3 . 9 0 0

JCR@2023

JCR Journal Grade:2

CAS Journal Grade:3

Cited Count:

WoS CC Cited Count: 4

SCOPUS Cited Count: 2

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 3

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