The　adsorptive　removal　of　typical　pharmaceuticals,　carbamazepine　(CBZ)　and　tetracycline　(TC),　was　investigated　with　four　zirconium-based　porphyrinic　metal-organic　frameworks　(MOFs)　(PCN-221,　PCN-222,　PCN-223,　and　PCN-224).　For　both　CBZ　and　TC,　the　adsorption　capacities　of　the　PCNs　were　ranked　in　the　following　order:　PCN-221　＜　PCN-223　＜　PCN-224　＜　PCN-222.　Notably,　this　order　aligns　with　the　BET　surface　areas　of　the　PCNs.　Cage-type　PCN-221　showed　a　lower　adsorption　capacity　than　the　other　three　channel-type　MOFs　due　to　its　small　apertures,　which　were　not　conducive　to　the　activation　of　PCN-221　and　space　utilization.　The　amount　of　adsorption　was　proportional　to　the　cumulative　pore　volume　in　PCNs　with　a　width　larger　than　that　of　the　CBZ/TC　molecule.　Therefore,　with　high　pore　volume　and　large　one-dimensional　channels　formed　by　ordered　linker　vacancies,　PCN-222　was　the　best　adsorbent　in　this　work.　According　to　the　Langmuir　model,　PCN-222　exhibited　exceptional　adsorption　capacities　for　CBZ　and　TC,　reaching　305　mg/g　and　280　mg/g,　respectively.　Additionally,　the　mechanisms　for　CBZ　removal　involved　hydrogen　bonding　and　π-π　interactions/stacking,　while　electrostatic　interactions,　hydrogen　bonding,　and　π-π　interactions/stacking　played　crucial　roles　in　TC　adsorption　onto　MOFs.　These　findings　establish　a　profound　comprehension　of　the　interplay　between　pore　structure　and　performance,　providing　helpful　guidance　for　designing　MOFs　to　remove　emerging　contaminants　effectively.　©　2023