Flexible,　breathable,　low-temperature　tolerant,　and　degradable　strain　sensors　have　attracted　substantial　attention　for　varied　applications　in　interactive　wearable　devices,　artificial　prosthetics,　and　intelligent　robots.　Herein,　a　novel　breathable,　low-temperature　tolerant,　degradable,　and　sensitive　strain　sensor　is　developed　by　microbial　fermentation　technology.　The　resulting　strain　sensor　exhibited　excellent　gas　permeability,　about　13　times　higher　than　that　of　unfermented　hydrogel,　reliable　low-temperature　resistance　down　to　-20　°C,　and　robust　degradability　in　water　about　96　h.　The　strain　sensor　possessed　good　linearity　(a　correlation　coefficient　of　0.994)　in　an　ultrawide　sensing　range　(up　to　200%),　ultralow-detection　limit　(0.05%),　fast　response　and　recovery　(36　ms),　and　high　reproducibility　(1000　cycles).　Attributed　to　these　tremendous　strain　sensing　performances,　the　strain　sensor　is　able　to　accurately　monitor　both　subtle　physiological　activities　and　large　human　motions.　Furthermore,　these　strain　sensors　can　assemble　into　a　3D　array　for　sensing　tactile　signals　and　mapping　spatial　stress　distribution.　This　strain　sensor　also　can　apply　to　human-computer　interaction　to　react　the　wrist　movement.　Sensors　with　breathability,　low-temperature　tolerance,　and　degradability　in　this　work　are　expected　to　play　a　role　in　the　preparation　of　various　breathable　strain　sensors.　©　2023　Elsevier　Ltd