The　magnetic　Fe0/FeS2　composite　iron-based　catalyst　was　successfully　prepared　by　hydrothermal　method,　and　was　employed　to　mediate　a　heterogeneous　Fenton　system　for　the　remediation　of　a　typical　Fluoroquinolones　antibiotic　(norfloxacin,　NOF).　The　SEM-Mapping　results　showed　that　the　Fe0/FeS2　composite　was　composed　of　Fe　and　S　elements,　and　displayed　granular　structure　with　different　sizes.　The　characterization　results　of　XRD,　XPS,　Raman　and　Magnetic　Measurement　System　(VSM)　showed　that　the　Fe0/FeS2　composite　material　had　been　successfully　prepared　with　good　magnetic　properties.　The　results　of　NOF　degradation　experiments　showed　that　the　optimal　conditions　of　Fe0/FeS2/H2O2　system　for　norfloxacin　degradation　were　initial　pH=5,　norfloxacin　initial　concentration　of　20　mg·L−1,　Fe0/FeS2　dosage　of　0.2　g·L−1,　H2O2　concentration　of　0.051　g·L−1.　The　heterogeneous　Fenton　system　could　instantaneously　degrade　99.27%　of　NOF　in　10　min,　and　the　Fe0/FeS2　exhibited　a　good　reusability.　After　3　runs,　the　degradation　efficiency　of　NOF　was　still　over　75%.　Under　the　attack　of　·OH,　norfloxacin　may　break　the　C-F　bond　and　open　the　ring　of　piperazine　and　quinolone,　and　finally　small　molecular　substances　such　as　F−,　H2O,　CO2　and　NO3−　will　be　generated.　©　2023　Science　Press.　All　rights　reserved.