Highly　stable　SiO2-coated　multiple　CuFe　nanoparticles　(CuFe@SiO2)　were　prepared　by　combining　a　facile　thermal　decomposition　and　the　reverse　microemulsion　method.　In　the　test　of　CO　hydrogenation　for　higher　alcohols　synthesis　(HAS),　it　was　found　that　the　prepared　CuFe@SiO2　catalyst　showed　higher　CO　conversion,　C2+OH　selectivity　and　a　superior　stability　than　those　of　CuFe　catalyst　with　time　on　stream.　This　could　be　related　to　the　space　confined　effect　of　the　core-shell　structure　that　inhibited　the　sintering　and　phase　separation　of　the　Cu-chi-Fe5C2　phase,　known　as　the　dual　active　sites　for　alcohols　formation,　which　inherently　improved　the　catalytic　performance　of　the　sample.　Furthermore,　the　correlation　between　the　catalytic　performance　and　the　structural　evolution　was　also　discussed.　The　CuFe@SiO2　catalysts　maintained　the　Cu-chi-Fe5C2　dual　active　sites　without　sintering　and　phase　separation,　and　thus　showed　the　higher　and　superior　stable　C2+OH　selectivity.　[GRAPHICS]　.