Antidepressants　are　gaining　public　attention　because　of　increasing　reports　of　their　occurrence　in　environment　and　their　potential　impact　on　ecosystems　and　human　health.　Continuous　input　of　pharmaceuticals　into　rivers,　through　psychiatric　hospital　or　wastewater　treatment　plant　(WWTPs)　effluent,　may　cause　adverse　effects　on　the　aquatic　ecosystems　of　the　receiving　water　bodies.　This　work　investigates　the　occurrence　and　sources　of　8　antidepressants　in　main　stream　and　tributaries　of　Huangpu　River　in　Shanghai.　The　detected　concentrations　of　the　selected　antidepressants　ranged　from　low　nanogram　per　liter　to　42.9　ng　L-1　(fluoxetine)　in　main　stream　and　ranged　from　low　nanogram　per　liter　to　33.7　ng　L-1　(fluoxetine)　in　tributaries.　To　study　the　effect　of　hospital　or　wastewater　treatment　plants　(WWTPs)　on　environment,　the　upstream　and　downstream　samples　were　analyzed.　Generally,　antidepressants　had　greater　concentrations　in　downstream　than　that　in　upstream　of　the　WWTPs　or　hospitals.　It　is　suggesting　that　WWTPs　and　hospitals　may　introduce　pollution　into　water　environment.　A　preliminary　risk　assessment　was　conducted:　none　of　the　eight　target　compounds　yielded　risk　quotient　(RQ)　values　more　than　0.1,　thus　indicating　that　no　adverse　effect　is　expected　in　water　environment.　These　results　will　provide　background　data　for　future　antidepressants　pollution　control　and　management　in　Shanghai,　China.