The　present　study　determined　concentrations　of　estrogenic　bisphenol　A　(BPA),　nonylphenol,　octylphenol　(4-tert-octylphenol),　butylphenol　(4-tert-butylphenol),　and　progestogenic　norethindrone　by　liquid　chromatography-tandem　mass　spectrometry　in　bile　extracts　from　field　fish　from　the　Xin＇an　River　and　market　fish　in　Shanghai,　China.　Compared　with　the　field　fish,　endocrine　disrupting　chemical　(EDC)　concentrations　in　market　fish　bile　were　at　relatively　high　levels　with　high　detectable　rates.　The　average　concentrations　of　BPA,　nonylphenol,　4-tert-octylphenol,　4-tert-butylphenol,　and　norethindrone　in　field　fish　bile　were　30.1　mu　g/L,　203　mu　g/L,　4.69　mu　g/L,　7.84　mu　g/L,　and　0.514　mu　g/L,　respectively;　in　market　fish　bile　they　were　240　mu　g/L,　528　mu　g/L,　76.5　mu　g/L,　12.8　mu　g/L,　and　5.26　mu　g/L,　respectively;　and　in　the　surface　water　of　Xin＇an　River　they　were　38.8　ng/L,　7.91　ng/L,　1.98　ng/L,　2.66　ng/L,　and　0.116　ng/L,　respectively.　The　average　of　total　estrogenic　activity　of　river　water　was　3.32　ng/L　estradiol　equivalents.　High　bioconcentration　factors　(BCFs)　were　discovered　for　all　5　EDCs　(＞=　998-fold)　in　field　fish　bile.　Furthermore,　the　authors　analyzed　the　BCF　value　of　BPA　in　fish　bile　after　30-d　exposure　to　environmentally　relevant　concentrations　of　BPA　in　the　laboratory,　and　the　analysis　revealed　that　BCF　in　fish　bile　(BCFFish　bile)　changed　in　an　inverse　concentration-dependent　manner　based　on　the　log10-transformed　BPA　concentration　in　water.　Strikingly,　the　data　from　the　field　study　were　well　fitted　within　this　trend.　The　data　together　suggested　that　analysis　of　fish　bile　extracts　could　be　an　efficient　method　for　assessing　waterborne　EDCs　exposure　for　aquatic　biota.　(C)　2015　SETAC