Application　of　nanotechnology　and　nanomaterials　in　cancer　therapeutics　has　attracted　much　attention　in　recent　years.　Nano　titanium　dioxide　is　one　of　the　most　important　inorganic　functional　materials.　Cellular　toxicity　of　pH-controlled　antitumor　drug　release　system　of　titanium　dioxide　nanotubes　(TiO2-NTs)　in　pancreatic　cancer　cells　(SW1990)　was　evaluated　in　this　paper.　The　anticancer　drug,　doxorubicin　(DOX)　was　easily　loaded　on　TiO2-NTs　through　adsorption　forces　because　of　its　high　specific　surface　area　and　perfect　surface　activity.　The　drug　release　from　the　nanotubes　was　pH　dependent.　The　toxicological　effects　were　studied　after　co-incubation　of　SW1990　with　TiO2-NTs-DOX,　TiO2-NTs　and　DOX,　respectively.　The　cellular　effect　of　DOX　released　from　the　TiO2-NTs-DOX　was　same　as　when　DOX　was　used　alone,　indicating　that　the　synthesized　TiO2-NTs　are　well　qualified　as　drug　carriers　in　antitumor　drug　controlled-release　system.