Microcystin-LR　(MC-LR),　a　problematic　potent　cyanotoxin,　is　produced　by　a　variety　of　cyanobacteria.　The　presence　of　MC-LR　in　drinking　water　is　a　severe　threat　to　human　health　as　well　as　an　environmental　concern.　The　control　of　these　algal　blooms　and　their　associated　toxins　is　critical　for　ensuring　safe　drinking　water　to　significant　populations.　To　the　best　of　our　knowledge,　this　is　the　first　detailed　study　about　the　application　of　Electron　Beam　Irradiation　(EBI)　for　the　control　of　Microcystis　aeruginosa　algae　cultures　and　simultaneous　degradation　of　MC-LR.　The　effects　of　EBI　dose　on　MC　production　and　removal　efficiency　were　investigated　by　measuring　intercellular　and　extracellular　MC　concentrations.　The　dramatic　decreases　in　MC　concentration　in　the　cells　and　solution　were　observed　under　our　experimental　conditions.　The　correlation　between　Chl-a　and　MC　concentrations　is　eliminated.　The　inhibition　of　cell　growth　and　degradation　of　MC-LR　by　EBI　is　highly　efficient　during　radiolysis.