Based　on　the　reverse　microemulsion　technique,　luminescent　dye　doped　core-shell　nanoparticles　have　been　prepared　by　employing　silica　as　the　shell　and　Rubpy　as　the　core　of　the　nanoparticles,　which　have　an　excellent　solubility　and　dispersibility,　especially　amine　groups　have　been　modified　on　their　surface　synchronously.　In　comparison　with　Rubpy,　these　nanoparticles　show　superiority　in　chemical　and　photo-chemical　stability.　The　Rubpy　doped　core-shell　nanoparticles　successfully　recognize　neural　stem　cells.