The　scaling-induced　wetting　phenomenon　seriously　affects　the　application　of　membrane　distillation　(MD)　technology　in　hypersaline　wastewater　treatment.　Unlike　the　large　amount　of　researches　on　membrane　scaling　and　membrane　wetting,　scaling-induced　wetting　is　not　sufficiently　studied.　In　this　work,　the　current　research　evolvement　of　scaling-induced　wetting　in　MD　was　systematically　summarized.　Firstly,　the　theories　involving　scaling-induced　wetting　were　discussed,　including　evaluation　of　scaling　potential　of　specific　solutions,　classical　and　non-classical　crystal　nucleation　and　growth　theories,　observation　and　evolution　of　scaling-induced　processes.　Secondly,　the　primary　pretreatment　methods　for　alleviating　scaling-induced　wetting　were　discussed　in　detail,　focusing　on　adding　agents　composed　of　coagulation,　precipitation,　oxidation,　adsorption　and　scale　inhibitors,　filtration　including　granular　filtration,　membrane　filtration　and　mesh　filtration　and　application　of　external　fields　including　sound,　light,　heat,　electromagnetism,　magnetism　and　aeration.　Then,　the　roles　of　operation　conditions　and　cleaning　conditions　in　alleviating　scaling-induced　wetting　were　evaluated.　The　main　operation　parameters　included　temperature,　flow　rate,　pressure,　ultrasound,　vibration　and　aeration,　while　different　types　of　cleaning　reagents,　cleaning　frequency　and　a　series　of　assisted　cleaning　measures　were　summarized.　Finally,　the　challenges　and　future　needs　in　the　application　of　nucleation　theory　to　scaling-induced　wetting,　the　speculation,　monitoring　and　mitigation　of　scaling-induced　wetting　were　proposed.