A Novel Superparamagnetic Multifunctional Nerve Scaffold: A Remote Actuation Strategy to Boost In Situ Extracellular Vesicles Production for Enhanced Peripheral Nerve Repair - Details

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Abstract：

Extracellular　vesicles　(EVs)　have　inherent　advantages　over　cell-based　therapies　in　regenerative　medicine　because　of　their　cargos　of　abundant　bioactive　cues.　Several　strategies　are　proposed　to　tune　EVs　production　in　vitro.　However,　it　remains　a　challenge　for　manipulation　of　EVs　production　in　vivo,　which　poses　significant　difficulties　for　EVs-based　therapies　that　aim　to　promote　tissue　regeneration,　particularly　for　long-term　treatment　of　diseases　like　peripheral　neuropathy.　Herein,　a　superparamagnetic　nanocomposite　scaffold　capable　of　controlling　EVs　production　on-demand　is　constructed　by　incorporating　polyethyleneglycol/polyethyleneimine　modified　superparamagnetic　nanoparticles　into　a　polyacrylamide/hyaluronic　acid　double-network　hydrogel　(Mag-gel).　The　Mag-gel　is　highly　sensitive　to　a　rotating　magnetic　field　(RMF),　and　can　act　as　mechano-stimulative　platform　to　exert　micro/nanoscale　forces　on　encapsulated　Schwann　cells　(SCs),　an　essential　glial　cell　in　supporting　nerve　regeneration.　By　switching　the　ON/OFF　state　of　the　RMF,　the　Mag-gel　can　scale　up　local　production　of　SCs-derived　EVs　(SCs-EVs)　both　in　vitro　and　in　vivo.　Further　transcriptome　sequencing　indicates　an　enrichment　of　transcripts　favorable　in　axon　growth,　angiogenesis,　and　inflammatory　regulation　of　SCs-EVs　in　the　Mag-gel　with　RMF,　which　ultimately　results　in　optimized　nerve　repair　in　vivo.　Overall,　this　research　provides　a　noninvasive　and　remotely　time-scheduled　method　for　fine-tuning　EVs-based　therapies　to　accelerate　tissue　regeneration,　including　that　of　peripheral　nerves.　©　2023　The　Authors.　Advanced　Materials　published　by　Wiley-VCH　GmbH.

Keyword：

extracellular vesicles magnetic nerve scaffolds mechanical actuation nerve regeneration Schwann cells

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[ 1 ] [Xia B.]Department of Orthopaedics, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China
[ 2 ] [Xia B.]Research and Development Center for Tissue Engineering, School of Stomatology, Fourth Military Medical University, Xi'an, 710032, China
[ 3 ] [Gao X.]Department of Orthopaedics, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China
[ 4 ] [Qian J.]College of Chemical Engineering, Fuzhou University, Xueyuan Road, Fuzhou, 350108, China
[ 5 ] [Li S.]Department of Orthopaedics, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China
[ 6 ] [Yu B.]Department of Neurosurgery, The Second Affiliated Hospital of Xi'an Jiao Tong University, Xi'an, 710032, China
[ 7 ] [Hao Y.]Department of Orthopaedics, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China
[ 8 ] [Wei B.]Department of Orthopaedics, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China
[ 9 ] [Ma T.]Department of Orthopaedics, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China
[ 10 ] [Wu H.]Department of Orthopaedics, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China
[ 11 ] [Yang S.]Department of Neurosurgery, The Second Affiliated Hospital of Xi'an Jiao Tong University, Xi'an, 710032, China
[ 12 ] [Zheng Y.]Department of Orthopaedics, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China
[ 13 ] [Gao X.]School of Ecology and Environment, Northwestern Polytechnical University, Xi'an, 710072, China
[ 14 ] [Guo L.]Department of Orthopaedics, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China
[ 15 ] [Gao J.]Department of Orthopaedics, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China
[ 16 ] [Yang Y.]Department of Orthopaedics, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China
[ 17 ] [Zhang Y.]Department of Neurosurgery, The Second Affiliated Hospital of Xi'an Jiao Tong University, Xi'an, 710032, China
[ 18 ] [Wei Y.]Department of Orthopaedics, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China
[ 19 ] [Xue B.]Department of Orthopaedics, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China
[ 20 ] [Jin Y.]Research and Development Center for Tissue Engineering, School of Stomatology, Fourth Military Medical University, Xi'an, 710032, China
[ 21 ] [Luo Z.]Department of Orthopaedics, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China
[ 22 ] [Zhang J.]College of Chemical Engineering, Fuzhou University, Xueyuan Road, Fuzhou, 350108, China
[ 23 ] [Huang J.]Department of Orthopaedics, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China

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Advanced Materials

ISSN： 0935-9648

Year： 2024

Issue： 3

Volume： 36

2 7 . 4 0 0

JCR@2023

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SCOPUS Cited Count： 5

ESI Highly Cited Papers on the List： 0 Unfold All

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