Extracellular　vesicles　(EVs)　have　inherent　advantages　over　cell-based　therapies　in　regenerative　medicine　because　of　their　cargos　of　abundant　bioactive　cues.　Several　strategies　are　proposed　to　tune　EVs　production　in　vitro.　However,　it　remains　a　challenge　for　manipulation　of　EVs　production　in　vivo,　which　poses　significant　difficulties　for　EVs-based　therapies　that　aim　to　promote　tissue　regeneration,　particularly　for　long-term　treatment　of　diseases　like　peripheral　neuropathy.　Herein,　a　superparamagnetic　nanocomposite　scaffold　capable　of　controlling　EVs　production　on-demand　is　constructed　by　incorporating　polyethyleneglycol/polyethyleneimine　modified　superparamagnetic　nanoparticles　into　a　polyacrylamide/hyaluronic　acid　double-network　hydrogel　(Mag-gel).　The　Mag-gel　is　highly　sensitive　to　a　rotating　magnetic　field　(RMF),　and　can　act　as　mechano-stimulative　platform　to　exert　micro/nanoscale　forces　on　encapsulated　Schwann　cells　(SCs),　an　essential　glial　cell　in　supporting　nerve　regeneration.　By　switching　the　ON/OFF　state　of　the　RMF,　the　Mag-gel　can　scale　up　local　production　of　SCs-derived　EVs　(SCs-EVs)　both　in　vitro　and　in　vivo.　Further　transcriptome　sequencing　indicates　an　enrichment　of　transcripts　favorable　in　axon　growth,　angiogenesis,　and　inflammatory　regulation　of　SCs-EVs　in　the　Mag-gel　with　RMF,　which　ultimately　results　in　optimized　nerve　repair　in　vivo.　Overall,　this　research　provides　a　noninvasive　and　remotely　time-scheduled　method　for　fine-tuning　EVs-based　therapies　to　accelerate　tissue　regeneration,　including　that　of　peripheral　nerves.　A　Mag-gel　with　applied　rotating　magnetic　field　(RMF)　serves　as　a　mechano-stimulative　platform　to　exert　micro/nanoscale　forces　to　nearby　Schwann　cells,　which　can　subsequently　scale　up　local　extracellular　vesicles　(EVs)　production　both　in　vitro　and　in　vivo.　As　a　non-invasive　strategy,　application　of　an　RMF　to　manipulate　the　local　EVs　production　via　the　Mag-gel　offers　a　remote　time-scheduled　approach　to　optimize　the　process　of　peripheral　nerve　regeneration.image