Photo-responsive　synergetic　therapeutics　achieved　significant　attraction　in　cancer　theranostic　due　to　the　versatile　characteristics　of　nanomaterials.　There　have　been　substantial　efforts　in　developing　the　simplest　nano-design　with　exceptional　synergistic　properties　and　multifunctionalities.　In　this　work,　biocompatible　Ti2C　MXene　nano　bipyramids　(MNBPs)　were　synthesized　by　hydrothermal　method　with　dual　functionalities　of　photothermal　and　photodynamic　therapies.　The　MNBPs　shape　was　obtained　from　two-dimensional　(2D)　Ti2C　nanosheets　by　controlling　the　temperature　of　the　reaction　mixture.　The　structure　of　these　Ti2C　MNBPs　was　characterized　by　a　high-resolution　transmission　electron　microscope,　scanning　electron　microscope,　atomic　force　microscope,　X-ray　photoelectron　spectroscopy,　and　X-ray　diffraction.　The　Ti2C　NBPs　have　shown　exceptional　photothermal　properties　with　increased　temperature　to　72.3　°C　under　808　nm　laser　irradiation.　The　designed　nano　bipyramids　demonstrated　excellent　cellular　uptake　and　biocompatibility.　The　Ti2C　NBP　has　established　a　remarkable　photothermal　therapy　(PTT)　effect　against　4T1　breast　cancer　cells.　Moreover,　Ti2C　NBPs　showed　a　profound　response　to　UV　light　(6　mW/cm2)　and　produced　reactive　oxygen　species,　making　them　useful　for　photodynamic　therapy　(PDT).　These　in-vitro　studies　pave　a　new　path　to　tune　the　properties　of　photo-responsive　MXene　nanosheets,　indicating　a　potential　use　in　biomedical　applications.　©　2024　Wiley-VCH　GmbH.