Alloying　(or　doping)　non-metals　with　platinum　(Pt)　is　an　advanced　solution　for　the　development　of　high-performance　Pt-based　electrocatalysts　for　oxygen　reduction　reaction　(ORR)　in　proton　exchange　membrane　fuel　cells　(PEMFCs).　Herein,　we　report　boron　(B)-alloyed　Pt　nanospheres　(B-PtNSs)　with　a　porous　network　nanostructure　by　a　combination　strategy　of　confinement　reduction　and　post-boronation.　B-alloying　can　induce　effective　electronic/geometric　structures,　strong　Pt-B　coordination,　and　lowered　d-band　center　to　weaken　the　binding　energy　of　oxygenated　intermediates　on　the　Pt　surface.　The　H2-O2　PEMFC　with　such　a　B-PtNSs/C　as　the　cathode　catalyst　can　reach　a　maximum　power　density　of　1.49　W　cm−2,　about　1.28　times　higher　than　that　of　Pt/C.　After　30,000　voltage　cycles　in　the　range　of　0.6　∼　0.95　V,　only　a　14.1　%　loss　of　initial　peak　power　density　can　be　observed,　while　that　with　Pt/C　declines　45.7　%.　Non-metals　alloying　with　Pt-based　nanostructures　can　enable　high-performance　ORR　electrocatalysts　for　their　practical　application　in　PEMFCs.　©　2024　Elsevier　B.V.