In　this　study,　we　synthesized　multi-nuclear　indium　oxide　clusters　(InOCs)　using　1,1′-ferrocene　dicarboxylic　acid　(H2FcDCA)　as　the　chelating　and　surface　protection　ligand.　The　obtained　clusters　include　the　cubane-type　heptanuclear　InOCs　([In7])　and　the　sandwich-type　thirteen-nuclear　InOCs　([In13]).　Notably,　[In13]　represents　the　highest　nuclear　number　reported　within　the　InOC　family.　In　addition,　the　presence　of　labile　coordination　sites　in　these　clusters　allowed　for　structural　modification　and　self-assembly.　A　series　of　[In7]　clusters　with　adjustable　band　gaps　have　been　obtained　and　the　self-assembly　of　[In7]　clusters　resulted　in　the　formation　of　an　Fe-doped　dimer,　[Fe2In12],　and　an　imidazole-bridged　tetramer,　[In28].　Similarly,　in　the　case　of　[In13]　clusters,　the　coordinated　water　molecules　could　be　replaced　by　imidazole,　methylimidazole,　and　even　a　bridged　carboxylic　acid,　allowing　the　construction　of　one-dimensional　extended　structures.　Additionally,　part　of　the　H2FcDCA　could　be　substituted　by　pyrazole.　This　flexibility　in　replacing　solvent　molecules　offered　diverse　possibilities　for　tailoring　the　properties　and　structures　of　the　InOCs　to　suit　specific　applications.　©　2024　The　Royal　Society　of　Chemistry.