Microbial　fuel　cells　(MFCs)　are　a　potential　biotechnology　for　simultaneous　degradation　of　organic　wastewater　and　power　generation.　In　this　paper,　a　biocompatible　composite　is　constructed　around　a　copper　mesh　with　sodium　alginate/agar　and　activated　carbon　(CM‐SA/AC)　and　acts　as　an　efficient　anode　for　MFCs　after　being　microbe　immobilized.　The　power　performance　of　the　MFC　with　CM‐SA/AC　anode　is　investigated.　The　results　show　that　the　addition　of　activated　carbon　is　conducive　to　the　immobilization　of　bacteria　on　CM‐SA/AC　anode　and　fast　start‐up　of　MFCs.　The　power　density　reaches　1088.6 mW/m2,　which　is　2.03　times　and　1.75　times　that　of　CM‐SA　(without　activated　carbon)　anode　and　carbon　felt　anode,　respectively.　In　case　of　a　candied　wastewater　treatment,　the　MFC　with　immobilized　CM‐SA/AC　anode　exhibits　a　much　higher　power　density　(724.5 mW/m2)　than　that　with　carbon　felt　anode　(145.0 mW/m2),　together　with　a　longer　stabilization　time　and　a　smaller　charge‐transfer　resistance.　The　total　removal　rate　of　chemical　oxygen　demand　(COD)　reaches　79.4 ± 0.65%.　The　present　study　will　facilitate　the　development　of　inexpensive　and　biocompatible　anodes　to　facilitate　the　application　of　MFCs　in　wastewater　treatment.