Tetracycline　(TC)　antibiotics,　extensively　utilized　in　livestock　farming　and　aquaculture,　pose　significant　environmental　challenges.　Photocatalysis,　leveraging　renewable　sunlight　and　reusable　photocatalysts,　offers　a　promising　avenue　for　mitigating　TC　pollution.　However,　identifying　robust　photocatalysts　remains　a　formidable　challenge.　This　study　introduces　a　novel　hollow　-flower　-ball　-like　nanoheterojunction　composed　of　a　nitrogen　-rich　covalent　organic　framework　(N-COF)　coupled　with　BiOBr　(BOB),　a　semiconductor　with　a　higher　Fermi　level.　The　synthesized　N-COF/BOB　S　-scheme　nanoheterojunction　features　an　expanded　contact　interface,　strengthened　chemical　bonding,　and　unique　band　topologies.　The　N-COF/BOB　composites　showcased　exceptional　TC　degradation　performance,　achieving　an　81.2%　removal　of　60　mg/L　TC　within　2　h,　markedly　surpassing　the　individual　efficiencies　of　N-COF　and　BOB　by　factors　of　3.80　and　5.96,　respectively.　Furthermore,　the　total　organic　carbon　(TOC)　removal　efficiency　highlights　a　superior　mineralization　capacity　in　the　N-COF/BOB　composite　compared　to　the　individual　components,　N-COF　and　BOB.　The　toxicity　assessment　revealed　that　the　degradation　intermediates　possess　diminished　environmental　toxicity.　This　enhanced　performance　is　ascribed　to　the　robust　Sscheme　nanoheterojunction　structure,　which　promotes　efficient　photoinduced　electron　transfer　from　BOB　to　NCOF.　This　process　also　augments　the　separation　of　photogenerated　charge　carriers,　resulting　in　an　increased　yield　of　superoxide　radicals　(center　dot　O2　)　and　hydroxyl　radicals　(center　dot　OH).　These　reactive　species　significantly　contribute　to　the　degradation　and　mineralization　of　TC.　Consequently,　this　study　introduces　a　sustainable　approach　for　addressing　emerging　antibiotic　contaminants,　employing　COF-based　photocatalysts.