In　recent　years,　the　frequency　of　strokes　has　been　on　the　rise　year　by　year　and　has　become　the　second　leading　cause　of　death　around　the　world,　which　is　characterized　by　a　high　mortality　rate,　high　recurrence　rate,　and　high　disability　rate.　Ischemic　strokes　account　for　a　large　percentage　of　strokes.　A　reperfusion　injury　in　ischemic　strokes　is　a　complex　cascade　of　oxidative　stress,　neuroinflammation,　immune　infiltration,　and　mitochondrial　damage.　Conventional　treatments　are　ineffective,　and　the　presence　of　the　blood–brain　barrier　(BBB)　leads　to　inefficient　drug　delivery　utilization,　so　researchers　are　turning　their　attention　to　nano-drug　delivery　systems.　Functionalized　nano-drug　delivery　systems　have　been　widely　studied　and　applied　to　the　study　of　cerebral　ischemic　diseases　due　to　their　favorable　biocompatibility,　high　efficiency,　strong　specificity,　and　specific　targeting　ability.　In　this　paper,　we　briefly　describe　the　pathological　process　of　reperfusion　injuries　in　strokes　and　focus　on　the　therapeutic　research　progress　of　nano-drug　delivery　systems　in　ischemic　strokes,　aiming　to　provide　certain　references　to　understand　the　progress　of　research　on　nano-drug　delivery　systems　(NDDSs).　©　2024　by　the　authors.