As　COVID-19　coexists　with　humans,　the　need　for　home　oxygen　(O2)　generators　has　grown,　especially　for　those　with　heart　and　lung　conditions.　This　study　presents　a　prototype　of　an　electrolyte-free　proton-exchange　membrane　electrochemical　oxygen　generator　(EOG)　that　uses　pure　water　for　safe,　high-performance　operation.　The　development　of　a　novel　oxygen　evolution　reaction　catalyst,　PtxIryRu1-x-yO2,　and　an　efficient　membrane　electrode　assembly　has　improved　the　EOG＇s　performance,　achieving　a　1　L　min−1　oxygen　production　rate　and　over　600　h　of　stability.　Furthermore,　the　EOG　demonstrates　several　distinct　advantages　for　medical　applications,　including　(1)　directly　producing　sterile　and　medical-grade　O2　(purity　＞99.5%),　(2)　supporting　nearly　instantaneous　O2　supply　for　emergency　(startup　time　＜1　s),　(3)　supporting　portable　application　due　to　its　light　weight　(＜2　kg)　and　compact　size　(1　dm3),　and　(4)　ensuring　a　quiet　operating　condition　for　patients　(＜45　dB).　The　EOG,　boasting　unique　application　advantages,　significantly　outperforms　commercial　pressure　swing　adsorption　devices,　thereby　showcasing　its　considerable　potential　for　future　applications.　©　2024　The　Authors