Pressure　and　temperature,　as　common　physical　parameters,　are　important　for　monitoring　human　health.　In　contrast,　single-mode　monitoring　is　prone　to　causing　experimental　errors.　Herein,　we　innovatively　designed　a　dual-mode　flexible　sensing　platform　based　on　a　platinum/zinc-meso-tetrakis(4-carboxyphenyl)porphyrin　(Pt/Zn-TCPP)　nanozyme　for　the　quantitative　monitoring　of　carcinoembryonic　antigen　(CEA)　in　biological　fluids　with　pressure　and　temperature　readouts.　The　Pt/Zn-TCPP　nanozyme　with　catalytic　and　photothermal　efficiencies　was　synthesized　by　means　of　integrating　photosensitizers　into　porous　materials.　The　flexible　sensing　system　after　the　antigen-antibody　reaction　recognized　the　pressure　using　a　flexible　skin-like　pressure　sensor　with　a　digital　multimeter　readout,　whereas　the　temperature　was　acquired　via　the　photoheat　conversion　system　of　the　Pt/Zn-TCPP　nanozyme　under　808　nm　near-infrared　(NIR)　irradiation　using　a　portable　NIR　imaging　camera　on　a　smartphone.　Meanwhile,　the　dual-mode　flexible　sensing　system　was　carried　out　on　a　homemade　three-dimensional　(3D)-printed　device.　Results　revealed　that　the　developed　dual-mode　immunosensing　platform　could　exhibit　good　pressure　and　temperature　responses　within　the　dynamic　range　of　0.5-100　ng　mL-1　CEA　with　the　detection　limits　of　0.24　and　0.13　ng　mL-1,　respectively.　In　addition,　the　pressure　and　temperature　were　sensed　simultaneously　without　crosstalk　interference.　Importantly,　the　dual-mode　flexible　immunosensing　system　can　effectively　avoid　false　alarms　during　the　measurement,　thus　providing　great　potential　for　simple　and　low-cost　development　for　point-of-care　testing.　©　2024　American　Chemical　Society.