Near-infrared circularly polarized light triggered phototherapy based on hybrid CuInSe2 quantum dot hydrogels - Details

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Abstract：

For　malignant　tumor　phototherapy,　current　biomolecules-based　materials　face　challenges　such　as　limited　tissue　penetration,　insufficient　tumor　accumulation,　and　overlook　of　the　unique　benefits　of　chirality,　thus　hampering　their　phototherapeutic　efficiency.　Herein,　we　introduce　a　novel　near-infrared　circularly　polarized　(NIR-CP)　light-responsive　hybrid　CuInSe2@ZnS　(CISe@ZnS)　quantum　dots　(QDs)　hydrogel　(QDs@L/D-Gel),　which　showcases　distinctive　NIR　chiroptical　activity,　highly　enhanced　tumor　retention,　and　superior　photothermal/photodynamic　properties.　Particularly,　the　QDs@L-Gel　exhibits　a　prominently　improved　photothermal　conversion　efficiency　(PCE)　of　43　%　and　elevated　reactive　oxygen　species　(ROS)　upon　808-nm　CP　light　irradiation,　outperforming　those　of　linearly　polarized　light　directly　emitted　from　a　laser　device.　Moreover,　a　remarkably　enhanced　phototherapeutic　efficacy　(tumor　inhibition　rate　=　83　%)　can　be　achieved　for　QDs@L-Gel　treated　mice　after　808-nm　CP　light　treatment,　without　any　toxic　side　effects.　Our　findings　highlight　the　importance　of　supramolecular　chirality　in　NIR-CP-mediated　phototherapy,　thereby　paving　a　new　avenue　for　more　advanced　and　effective　tumor　treatment　in　clinical　applications.　©　2024　Elsevier　Ltd

Keyword：

CuInSe2 Near-infrared Phototherapy Self-assembly Supramolecular chirality

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[ 1 ] [Gao H.]State Key Laboratory of Structural Chemistry, Fujian Key Laboratory of Nanomaterials, and CAS Key Laboratory of Design and Assembly of Functional Nanostructures, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fujian, Fuzhou, 350002, China
[ 2 ] [Gao H.]College of Chemistry, Fuzhou University, Fujian, Fuzhou, 350108, China
[ 3 ] [Liu Y.]State Key Laboratory of Structural Chemistry, Fujian Key Laboratory of Nanomaterials, and CAS Key Laboratory of Design and Assembly of Functional Nanostructures, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fujian, Fuzhou, 350002, China
[ 4 ] [Liu Y.]Fujian Science & Technology Innovation Laboratory for Optoelectronic Information of China, Fujian, Fuzhou, 350108, China
[ 5 ] [Lian W.]State Key Laboratory of Structural Chemistry, Fujian Key Laboratory of Nanomaterials, and CAS Key Laboratory of Design and Assembly of Functional Nanostructures, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fujian, Fuzhou, 350002, China
[ 6 ] [Lian W.]College of Chemistry, Fuzhou University, Fujian, Fuzhou, 350108, China
[ 7 ] [Hu P.]State Key Laboratory of Structural Chemistry, Fujian Key Laboratory of Nanomaterials, and CAS Key Laboratory of Design and Assembly of Functional Nanostructures, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fujian, Fuzhou, 350002, China
[ 8 ] [Shang X.]State Key Laboratory of Structural Chemistry, Fujian Key Laboratory of Nanomaterials, and CAS Key Laboratory of Design and Assembly of Functional Nanostructures, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fujian, Fuzhou, 350002, China
[ 9 ] [Chen M.]College of Biological Science and Engineering, Fuzhou University, Fujian, Fuzhou, 350108, China
[ 10 ] [Song X.]MOE Key Laboratory for Analytical Science of Food Safety and Biology, State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fujian, Fuzhou, 350108, China
[ 11 ] [Song X.]College of Chemistry, Fuzhou University, Fujian, Fuzhou, 350108, China
[ 12 ] [Guan T.]State Key Laboratory of Structural Chemistry, Fujian Key Laboratory of Nanomaterials, and CAS Key Laboratory of Design and Assembly of Functional Nanostructures, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fujian, Fuzhou, 350002, China
[ 13 ] [Guan T.]Fujian Science & Technology Innovation Laboratory for Optoelectronic Information of China, Fujian, Fuzhou, 350108, China
[ 14 ] [Chen X.]State Key Laboratory of Structural Chemistry, Fujian Key Laboratory of Nanomaterials, and CAS Key Laboratory of Design and Assembly of Functional Nanostructures, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fujian, Fuzhou, 350002, China
[ 15 ] [Chen X.]Fujian Science & Technology Innovation Laboratory for Optoelectronic Information of China, Fujian, Fuzhou, 350108, China
[ 16 ] [Chen X.]College of Chemistry, Fuzhou University, Fujian, Fuzhou, 350108, China

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Source ：

Nano Today

ISSN： 1748-0132

Year： 2024

Volume： 58

1 3 . 2 0 0

JCR@2023

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ESI Highly Cited Papers on the List： 0 Unfold All

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30 Days PV： 2

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