For　malignant　tumor　phototherapy,　current　biomolecules-based　materials　face　challenges　such　as　limited　tissue　penetration,　insufficient　tumor　accumulation,　and　overlook　of　the　unique　benefits　of　chirality,　thus　hampering　their　phototherapeutic　efficiency.　Herein,　we　introduce　a　novel　near-infrared　circularly　polarized　(NIR-CP)　lightresponsive　hybrid　CuInSe2@ZnS　(CISe@ZnS)　quantum　dots　(QDs)　hydrogel　(QDs@L/D-Gel),　which　showcases　distinctive　NIR　chiroptical　activity,　highly　enhanced　tumor　retention,　and　superior　photothermal/photodynamic　properties.　Particularly,　the　QDs@L-Gel　exhibits　a　prominently　improved　photothermal　conversion　efficiency　(PCE)　of　43　%　and　elevated　reactive　oxygen　species　(ROS)　upon　808-nm　CP　light　irradiation,　outperforming　those　of　linearly　polarized　light　directly　emitted　from　a　laser　device.　Moreover,　a　remarkably　enhanced　phototherapeutic　efficacy　(tumor　inhibition　rate　=　83　%)　can　be　achieved　for　QDs@L-Gel　treated　mice　after　808-nm　CP　light　treatment,　without　any　toxic　side　effects.　Our　findings　highlight　the　importance　of　supramolecular　chirality　in　NIR-CP-mediated　phototherapy,　thereby　paving　a　new　avenue　for　more　advanced　and　effective　tumor　treatment　in　clinical　applications.