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author：

Chen, Y. (Chen, Y..) [1] | Lin, G. (Lin, G..) [2] | Wang, Z. (Wang, Z..) [3] | He, J. (He, J..) [4] | Yang, G. (Yang, G..) [5] | Lin, Z. (Lin, Z..) [6] | Gong, C. (Gong, C..) [7] | Liu, N. (Liu, N..) [8] | Li, F. (Li, F..) [9] | Tong, D. (Tong, D..) [10] | Lin, Y. (Lin, Y..) [11] | Ding, J. (Ding, J..) [12] | Zhang, J. (Zhang, J..) [13] (Scholars：张进)

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Scopus

Abstract：

Traditional　hepatocellular　carcinoma-chip　models　lack　the　cell　structure　and　microenvironments　necessary　for　high　pathophysiological　correlation,　leading　to　low　accuracy　in　predicting　drug　efficacy　and　high　production　costs.　This　study　proposed　a　decellularized　hepatocellular　carcinoma-on-a-chip　model　to　screen　anti-tumor　nanomedicine.　In　this　model,　human　hepatocellular　carcinoma　(HepG2)　and　human　normal　liver　cells　(L02)　were　co-cultured　on　a　three-dimensional　(3D)　decellularized　extracellular　matrix　(dECM)　in　vitro　to　mimic　the　tumor　microenvironments　of　human　hepatocellular　carcinoma　in　vivo.　Additionally,　a　smart　nanomedicine　was　developed　by　encapsulating　doxorubicin　(DOX)　into　the　ferric　oxide　(Fe3O4)-incorporated　liposome　nanovesicle　(NLV/Fe+DOX).　NLV/Fe+DOX　selectively　killed　78.59%　±　6.78%　of　HepG2　cells　through　targeted　delivery　and　synergistic　chemo-chemodynamic-photothermal　therapies,　while　the　viability　of　surrounding　L02　cells　on　the　chip　model　retained　high,　at　over　90.0%.　The　drug　efficacy　tested　using　this　unique　chip　model　correlated　well　with　the　results　of　cellular　and　animal　experiments.　In　summary,　our　proposed　hepatocellular　carcinoma-chip　model　is　a　low-cost　yet　accurate　drug-testing　platform　with　significant　potential　for　drug　screening.　©　2024　Elsevier　B.V.

Keyword：

Decellularized extracellular matrix Drug screening Hepatocellular carcinoma-on-a-chip model Multi-functional nanomedicine Synergistic tumor therapy

Community：

  • [ 1 ] [Chen Y.]College of Chemical Engineering, Fuzhou University, 2 Xueyuan Road, Fuzhou, 350108, China
  • [ 2 ] [Chen Y.]Qingyuan Innovation Laboratory, 1 Xueyuan Road, Quanzhou, 362801, China
  • [ 3 ] [Lin G.]Department of Plastic surgery Shengli Clinical Medical College of Fujian Medical University, 134 Dongjie Road, Fuzhou, 350001, China
  • [ 4 ] [Wang Z.]College of Chemical Engineering, Fuzhou University, 2 Xueyuan Road, Fuzhou, 350108, China
  • [ 5 ] [Wang Z.]Qingyuan Innovation Laboratory, 1 Xueyuan Road, Quanzhou, 362801, China
  • [ 6 ] [He J.]College of Chemical Engineering, Fuzhou University, 2 Xueyuan Road, Fuzhou, 350108, China
  • [ 7 ] [He J.]Qingyuan Innovation Laboratory, 1 Xueyuan Road, Quanzhou, 362801, China
  • [ 8 ] [Yang G.]Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun, 130022, China
  • [ 9 ] [Lin Z.]Ruisi (Fujian) Biomedical Engineering Research Center Co., Ltd., Fuzhou, 350100, China
  • [ 10 ] [Gong C.]College of Chemical Engineering, Fuzhou University, 2 Xueyuan Road, Fuzhou, 350108, China
  • [ 11 ] [Gong C.]Qingyuan Innovation Laboratory, 1 Xueyuan Road, Quanzhou, 362801, China
  • [ 12 ] [Liu N.]College of Chemical Engineering, Fuzhou University, 2 Xueyuan Road, Fuzhou, 350108, China
  • [ 13 ] [Liu N.]Qingyuan Innovation Laboratory, 1 Xueyuan Road, Quanzhou, 362801, China
  • [ 14 ] [Li F.]College of Chemical Engineering, Fuzhou University, 2 Xueyuan Road, Fuzhou, 350108, China
  • [ 15 ] [Li F.]Qingyuan Innovation Laboratory, 1 Xueyuan Road, Quanzhou, 362801, China
  • [ 16 ] [Tong D.]MOE Key Laboratory for Analytical Science of Food Safety and Biology, State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, 2 Xueyuan Road, Fuzhou, 350108, China
  • [ 17 ] [Lin Y.]College of Chemical Engineering, Fuzhou University, 2 Xueyuan Road, Fuzhou, 350108, China
  • [ 18 ] [Lin Y.]Qingyuan Innovation Laboratory, 1 Xueyuan Road, Quanzhou, 362801, China
  • [ 19 ] [Ding J.]Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun, 130022, China
  • [ 20 ] [Zhang J.]College of Chemical Engineering, Fuzhou University, 2 Xueyuan Road, Fuzhou, 350108, China
  • [ 21 ] [Zhang J.]Qingyuan Innovation Laboratory, 1 Xueyuan Road, Quanzhou, 362801, China

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Source ：

Biosensors and Bioelectronics

ISSN： 0956-5663

Year： 2024

Volume： 264

1 0 . 7 0 0

JCR@2023

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ESI Highly Cited Papers on the List： 0 Unfold All

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30 Days PV： 1

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