An　electro-chemo-mechanical　model　is　developed　for　lithium-ion　battery　(LIB)　considering　the　damage　of　active　material　(AM)　particles.　The　established　model　is　used　to　evaluate　the　effect　of　stress　and　the　effect　of　damage　on　the　electro-chemo-mechanical　behavior　of　cathode.　The　cathode　is　generated　with　a　random　distribution　method.　Computational　results　show　that　moderate　stress　is　beneficial　for　the　battery　performance,　while　damage　generated　by　high　stress　can　considerably　degrade　the　battery　capacity.　The　impact　of　several　structural　factors　on　the　electro-chemo-mechanical　behaviors　of　LIB　are　investigated.　Smaller　particles　are　found　beneficial　for　the　battery　performance.　Furthermore,　the　computational　results　also　suggest　that　an　increasing　particle　size　from　the　separator　to　the　current　collector　leads　to　higher　capacity.　The　presented　model　helps　to　understand　the　electro-chemo-mechanical　coupling　mechanism　of　LIB.　Developed　an　electro-chemo-mechanical　model　considering　the　damage　of　AM　particles　Revealed　the　effect　of　stress　and　of　damage,　respectively.　Analysed　the　influence　of　three　particle　stacking　methods　Analysed　the　electro-chemo-mechanical　behavior　of　gradient　electrodes.