The　membrane　fouling　derived　from　the　accumulated　dust　pollutants　and　highly　viscous　oily　particles　causes　irreversible　damage　to　the　filtration　performance　of　air　filters　and　results　in　a　significant　reduction　in　their　service　life.　However,　it　is　still　challenging　to　construct　high-efficiency　and　antifouling　air　filtration　membranes　with　recyclable　regeneration.　Herein,　the　fluorine-free　amphiphobic　micro/nanofiber　composite　membrane　was　controllably　constructed　by　integrating　click　chemistry　reaction　and　electrospinning　technique.　Low-surface-energy　fibers　were　constructed　by　a　thiol-ene　click　chemical　reaction　between　mercaptosilane　and　vinyl　groups　of　polystyrene-butadiene-styrene　(SBS),　combined　with　hydroxyl-terminated　poly(dimethylsiloxane)　during　the　electrospinning　process.　The　functional　air　filter　is　then　prepared　by　the　two-layer　composite　strategy.　Because　of　the　advantages　of　liquid-like　fibrous　surface　and　micro/nanofibrous　porous　structure,　SBS/PAN　composite　membrane　simultaneously　shows　superior　antifouling　performances　of　pollutants　and　filtration　efficiency　of　over　97%　PM0.3　removal.　More　importantly,　the　antifouling　fibrous　membrane　still　presents　a　stable　and　efficient　filtration　efficiency　after　multiple　washes.　Its　service　life　in　dust　filtration　environments　is　approximately　1.7　times　longer　than　that　of　the　substrate　membrane.　This　work　may　provide　a　significant　reference　for　the　design　of　antifouling　fiber　membranes　and　high-efficiency　air　filters　with　long　life　spans　and　reusability.　©　2024　American　Chemical　Society.