Transition-metal and base-free ether synthesis via alcohol-participated yne-allylic substitution - Details

author：

Abstract：

Ethers　are　among　the　most　important　chemicals　in　organic　synthesis,　the　pharmaceutical　industry,　agrochemical　production,　and　material　science.　C-O　bond　formation　via　substitution　is　one　of　the　most　widely　used　strategies　for　ether　formation.　However,　known　methods　usually　employ　transition-metal　and　bases　to　facilitate　the　process.　In　this　work,　we　describe　the　base-　and　transition-metal-free　ether　formation　via　alcohol　and　phenol-participated　substitution.　The　protocol　allows　access　to　a　large　number　of　ethers　with　enyne　functional　moieties,　and　features　mild　reaction　conditions,　high　efficiency,　and　good　regio-　and　stereoselectivities.　The　reaction　could　be　readily　scaled　up,　and　the　products　could　be　used　in　a　range　of　further　transformations.

Keyword：

Alcohol Base free Ether synthesis Transition-metal free Yne-allylic substitution

Community：

[ 1 ] [Xu, Chao]Fuzhou Univ, Coll Chem, Fuzhou 350116, Peoples R China
[ 2 ] [Luo, Yingkun]Fuzhou Univ, Coll Chem, Fuzhou 350116, Peoples R China
[ 3 ] [Fang, Xinqiang]Fuzhou Univ, Coll Chem, Fuzhou 350116, Peoples R China
[ 4 ] [Xu, Chao]Univ Chinese Acad Sci, Fujian Inst Res Struct Matter, Ctr Excellence Mol Synth, State Key Lab Struct Chem, Fuzhou 350100, Peoples R China
[ 5 ] [Luo, Yingkun]Univ Chinese Acad Sci, Fujian Inst Res Struct Matter, Ctr Excellence Mol Synth, State Key Lab Struct Chem, Fuzhou 350100, Peoples R China
[ 6 ] [Niu, Shengtong]Univ Chinese Acad Sci, Fujian Inst Res Struct Matter, Ctr Excellence Mol Synth, State Key Lab Struct Chem, Fuzhou 350100, Peoples R China
[ 7 ] [Gong, Fan]Univ Chinese Acad Sci, Fujian Inst Res Struct Matter, Ctr Excellence Mol Synth, State Key Lab Struct Chem, Fuzhou 350100, Peoples R China
[ 8 ] [Lan, Shouang]Univ Chinese Acad Sci, Fujian Inst Res Struct Matter, Ctr Excellence Mol Synth, State Key Lab Struct Chem, Fuzhou 350100, Peoples R China
[ 9 ] [Yang, Shuang]Univ Chinese Acad Sci, Fujian Inst Res Struct Matter, Ctr Excellence Mol Synth, State Key Lab Struct Chem, Fuzhou 350100, Peoples R China
[ 10 ] [Fang, Xinqiang]Univ Chinese Acad Sci, Fujian Inst Res Struct Matter, Ctr Excellence Mol Synth, State Key Lab Struct Chem, Fuzhou 350100, Peoples R China
[ 11 ] [Xu, Chao]Univ Chinese Acad Sci, Fujian Inst Res Struct Matter, Ctr Excellence Mol Synth, Key Lab Coal Ethylene Glycol & Its Related Technol, Fuzhou 350100, Peoples R China
[ 12 ] [Luo, Yingkun]Univ Chinese Acad Sci, Fujian Inst Res Struct Matter, Ctr Excellence Mol Synth, Key Lab Coal Ethylene Glycol & Its Related Technol, Fuzhou 350100, Peoples R China
[ 13 ] [Niu, Shengtong]Univ Chinese Acad Sci, Fujian Inst Res Struct Matter, Ctr Excellence Mol Synth, Key Lab Coal Ethylene Glycol & Its Related Technol, Fuzhou 350100, Peoples R China
[ 14 ] [Gong, Fan]Univ Chinese Acad Sci, Fujian Inst Res Struct Matter, Ctr Excellence Mol Synth, Key Lab Coal Ethylene Glycol & Its Related Technol, Fuzhou 350100, Peoples R China
[ 15 ] [Lan, Shouang]Univ Chinese Acad Sci, Fujian Inst Res Struct Matter, Ctr Excellence Mol Synth, Key Lab Coal Ethylene Glycol & Its Related Technol, Fuzhou 350100, Peoples R China
[ 16 ] [Yang, Shuang]Univ Chinese Acad Sci, Fujian Inst Res Struct Matter, Ctr Excellence Mol Synth, Key Lab Coal Ethylene Glycol & Its Related Technol, Fuzhou 350100, Peoples R China
[ 17 ] [Fang, Xinqiang]Univ Chinese Acad Sci, Fujian Inst Res Struct Matter, Ctr Excellence Mol Synth, Key Lab Coal Ethylene Glycol & Its Related Technol, Fuzhou 350100, Peoples R China
[ 18 ] [Liu, Jinggong]Guangzhou Univ Chinese Med, Guangdong Prov Hosp Tradit Chinese Med, Affiliated Hosp 2, Orthoped Dept, Guangzhou 510120, Peoples R China
[ 19 ] [Luo, Benlong]Pingxiang Univ, Pingxiang 337055, Peoples R China

Reprint 's Address：

[Fang, Xinqiang]Fuzhou Univ, Coll Chem, Fuzhou 350116, Peoples R China;;[Niu, Shengtong]Univ Chinese Acad Sci, Fujian Inst Res Struct Matter, Ctr Excellence Mol Synth, State Key Lab Struct Chem, Fuzhou 350100, Peoples R China;;[Fang, Xinqiang]Univ Chinese Acad Sci, Fujian Inst Res Struct Matter, Ctr Excellence Mol Synth, State Key Lab Struct Chem, Fuzhou 350100, Peoples R China;;[Niu, Shengtong]Univ Chinese Acad Sci, Fujian Inst Res Struct Matter, Ctr Excellence Mol Synth, Key Lab Coal Ethylene Glycol & Its Related Technol, Fuzhou 350100, Peoples R China;;[Fang, Xinqiang]Univ Chinese Acad Sci, Fujian Inst Res Struct Matter, Ctr Excellence Mol Synth, Key Lab Coal Ethylene Glycol & Its Related Technol, Fuzhou 350100, Peoples R China;;[Liu, Jinggong]Guangzhou Univ Chinese Med, Guangdong Prov Hosp Tradit Chinese Med, Affiliated Hosp 2, Orthoped Dept, Guangzhou 510120, Peoples R China;;[Luo, Benlong]Pingxiang Univ, Pingxiang 337055, Peoples R China

Email：

1134882213@qq.com |
20010060@pxu.edu.cn |
liujinggong001@163.com |
xqfang@fjirsm.ac.cn

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