High molecular weight polysaccharides from Ganoderma lucidum attenuates inflammatory responses, gut microbiota, and liver metabolomic in lipopolysaccharide-induced liver injury mice - Details

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High　molecular　weight　polysaccharides　(GLPH,　≥300　kDa)　are　the　major　compounds　of　Ganoderma　lucidum　with　improving　liver　function.　However,　the　effect　of　GLPH　on　improving　acute　liver　injury　(ALI)　wasn＇t　revealed.　Herein,　the　ameliorating　effects　and　mechanisms　of　GLPH　were　revealed　in　lipopolysaccharide　(LPS)-ALI　mice.　The　results　indicated　that　GLPH　intervention　(100　mg/kg　day)　reduced　the　serum　ALT　(22.67　±　6.48　U/L),　AST　(21.19　±　7.08　U/L),　ALP　(56.98　±　12.71　U/L),　GGT　(1.48　±　0.22　U/L)　levels　in　ALI　mice　(p　©　2024

Keyword：

Diseases Liver Macroinvertebrates Metabolites

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[ 1 ] [Guo, Weiling]Institute of Food Science and Technology, College of Biological Science and Engineering, Fuzhou University, Fuzhou; 350108, China
[ 2 ] [Liu, Wenkun]Department of Cardiology, Fujian Medical University Union Hospital, Fuzhou; 350001, China
[ 3 ] [Liang, Peng]College of Food Science, Fujian Agriculture and Forestry University, Fuzhou; 350002, China
[ 4 ] [Ni, Li]Institute of Food Science and Technology, College of Biological Science and Engineering, Fuzhou University, Fuzhou; 350108, China
[ 5 ] [Lv, Xucong]Institute of Food Science and Technology, College of Biological Science and Engineering, Fuzhou University, Fuzhou; 350108, China
[ 6 ] [Fan, Jinlin]College of Food and Bioengineering, Fujian Polytechnic Normal University, Fuqing; 350300, China
[ 7 ] [Shi, Feifei]College of Food Science, Fujian Agriculture and Forestry University, Fuzhou; 350002, China

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Source ：

International Journal of Biological Macromolecules

ISSN： 0141-8130

Year： 2025

Volume： 287

7 . 7 0 0

JCR@2023

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WoS CC Cited Count：

SCOPUS Cited Count： 2

ESI Highly Cited Papers on the List： 0 Unfold All

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Chinese Cited Count：

30 Days PV： 1

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