Magnetic　nanoparticles　(MNPs)　used　for　magnetic　hyperthermia　can　not　only　damage　tumor　cells　after　elevating　to　a　specific　temperature　but　also　provide　the　temperature　required　for　thermosensitive　liposomes　(TSL)　to　release　doxorubicin　(DOX).　MNPs　injected　into　tumor　will　generate　heat　under　an　alternating　magnetic　field,　so　the　MNPs　distribution　can　determine　temperature　distribution　and　further　affect　the　DOX　concentration　used　for　tumor　therapy.　This　study　proposes　an　asynchronous　injection　strategy　for　this　combination　therapy　in　order　to　improve　the　DOX　concentration　value　for　drug　therapy,　in　which　the　MNPs　are　injected　into　tumor　after　a　certain　lagging　of　TSL　injection　in　order　to　increase　the　TSL　concentration　inside　tumor.　In　addition,　the　evaluation　of　treatment　effect　for　this　combination　therapy　is　implemented　by　considering　two　different　MNPs　concentration　distributions　and　two　biological　heat　transfer　models.　The　simulation　results　demonstrate　that　the　treatment　effect　for　combination　therapy　can　be　significantly　improved　after　considering　the　proposed　asynchronous　injection　strategy,　which　can　mainly　attribute　to　the　improvement　of　DOX　concentration.　The　DOX　concentration　difference　during　therapy　is　generally　relevant　to　both　the　lagging　time　of　different　injections　and　the　local　temperature　distribution　due　to　MNPs　concentration　distribution.