Here　we　report　a　highly　efficient　method　for　coupling　of　peroxypyrroloindolenines　with　amines　under　catalyst-free　conditions　to　obtain　stable　C2-N　peroxyindolenines　in　high　yields　with　remarkable　functional　group　tolerance.　Initial　studies　have　shown　that　compound　13　exhibits　potent　inhibition　of　the　B16/F10　cell　line　with　an　IC50　value　of　2.18　mu　M.