Micro-and-nano　plastics　(MNPs)　are　pervasive　in　terrestrial　ecosystems　and　represent　an　increasing　threat　to　plant　health;　however,　the　mechanisms　underlying　their　phytotoxicity　remain　inadequately　understood.　MNPs　can　infiltrate　plants　through　roots　or　leaves,　causing　a　range　of　toxic　effects,　including　inhibiting　water　and　nutrient　uptake,　reducing　seed　germination　rates,　and　impeding　photosynthesis,　resulting　in　oxidative　damage　within　the　plant　system.　The　effects　of　MNPs　are　complex　and　influenced　by　various　factors　including　size,　shape,　functional　groups,　and　concentration.　Recent　advancements　in　omics　technologies　such　as　proteomics,　metabolomics,　transcriptomics,　and　microbiomics,　coupled　with　emerging　technologies　like　4D　omics,　phenomics,　spatial　transcriptomics,　and　single-cell　omics,　offer　unprecedented　insight　into　the　physiological,　molecular,　and　cellular　responses　of　terrestrial　plants　to　MNPs　exposure.　This　literature　review　synthesizes　current　findings　regarding　MNPs-induced　phytotoxicity,　emphasizing　alterations　in　gene　expression,　protein　synthesis,　metabolic　pathways,　and　physiological　disruptions　as　revealed　through　omics　analyses.　We　summarize　how　MNPs　interact　with　plant　cellular　structures,　disrupt　metabolic　processes,　and　induce　oxidative　stress,　ultimately　affecting　plant　growth　and　productivity.　Furthermore,　we　have　identified　critical　knowledge　gaps　and　proposed　future　research　directions,　highlighting　the　necessity　for　integrative　omics　studies　to　elucidate　the　complex　pathways　of　MNPs　toxicity　in　terrestrial　plants.　In　conclusion,　this　review　underscores　the　potential　of　omics　approaches　to　elucidate　the　mechanisms　of　MNPs-phytotoxicity　and　to　develop　strategies　for　mitigating　the　environmental　impact　of　MNPs　on　plant　health.　©　2025　The　Author(s)