Despite　significant　progress　in　tissue　engineering,　the　full　regeneration　of　chronic　wounds　persists　as　a　major　challenge,　with　the　immune　response　to　tissue　damage　being　a　key　determinant　of　the　healing　process＇s　quality　and　duration.　Post-injury,　a　crucial　aspect　is　the　transition　of　macrophages　from　a　pro-inflammatory　state　to　an　anti-inflammatory.　Thus,　this　alteration　in　macrophage　polarization　presents　an　enticing　avenue　within　the　realm　of　regenerative　medicine.　Recent　advancements　have　entailed　the　integration　of　a　myriad　of　cellular　and　molecular　signals　into　hydrogel-based　constructs,　enabling　the　fine-tuning　of　immune　cell　activities　during　different　phases.　This　discussion　explores　modern　insights　into　immune　cell　roles　in　skin　regeneration,　underscoring　the　key　role　of　immune　modulation　in　amplifying　the　overall　efficacy　of　wounds.　Moreover,　a　comprehensive　review　is　presented　on　the　latest　sophisticated　technologies　employed　in　the　design　of　immunomodulatory　hydrogels　to　regulate　macrophage　polarization.　Furthermore,　the　deliberate　design　of　hydrogels　to　deliver　targeted　immune　stimulation　through　manipulation　of　chemistry　and　cell　integration　is　also　emphasized.　Moreover,　an　overview　is　provided　regarding　the　influence　of　hydrogel　properties　on　immune　traits　and　tissue　regeneration　process.　Conclusively,　the　accent　is　on　forthcoming　pathways　directed　toward　modulating　immune　responses　in　the　milieu　of　chronic　healing.　©　2024　The　Author(s).　Advanced　Science　published　by　Wiley-VCH　GmbH.