2,2-methylenebis(4-chlorophenol)　also　known　as　dichlorophen　(Dcp)　is　a　highly　toxic　environmental　pollutant　that　persists　at　low　concentrations　and　is　notoriously　resistant　to　degradation.　Consequently,　it　is　highly　important　to　develop　a　simple　and　rapid　detection　assay　for　Dcp.　This　study　presents　a　one-pot　synthesis　of　novel　nanocomposites　based　on　a　lanthanum-based　metal-organic　framework　(La-MOF),　water-soluble　β-cyclodextrin　(β-CD)　and　fullerene　(C60).　La-MOF@C60/β-CD　nanocomposite　was　integrated　into　a　glassy　carbon　electrode　(GCE)　to　create　a　new　electrochemical　sensor　for　Dcp　detection.　La-MOFs　have　a　large　specific　surface　area　with　copious　electrocatalytic　active　sites,　but　the　low　conductivity　of　La-MOF　limits　its　electrochemical　performance.　To　overcome　this,　the　conductivity　was　improved　by　the　incorporation　of　C60　into　La-MOF.　Furthermore,　the　host-guest　interaction　facilitated　by　β-CD　endows　the　La-MOF@C60/β-CD-modified　electrode　with　superior　electrocatalytic　activity　towards　Dcp　oxidation.　The　resulting　sensor　offers　sensitive　Dcp　detection,　with　a　linear　response　range　from　30　nM　to　25　μM　and　a　limit　of　detection　(LOD)　of　11.6　nM.　It　also　exhibits　excellent　signal　reproducibility,　sensor　stability,　and　selectivity　towards　Dcp.　Furthermore,　the　strategy　was　effectively　applied　to　the　determination　of　Dcp　in　real　water　samples,　achieving　satisfactory　recoveries　between　93.3　%　and　102.6　%.　©　2025　Elsevier　Ltd