Motor　dysfunction　is　the　main　symptom　after　stroke,　which　is　generally　thought　to　be　caused　by　the　damage　of　neural　network　that　controls　motor　function.　To　explore　the　neuromuscular　control　mechanism　of　stroke　patients,　in　this　paper,　the　functional　cortical　muscular　coupling　(FCMC)　is　used　as　a　tooi　to　collect　the　electroencephalogram　(EEG)　signals　of　13　stroke　patients　and　13　healthy　controls　during　the　extension　movement.　Meanwhile,　the　Electromyogram　(EMG)　signals　of　triceps　brachii,　anterior　deltoid　toe,　middletoe,　back　toe,　biceps　brachii,　pectoralis　major　and　trapezius　muscle　are　obtained　by　FCMC.　Moreover,　by　locating　the　cerebral　cortex　source,　the　raw　EEG　signal　is　obtained,　afterwards　the　active　brain　region　corresponding　to　the　action　is　also　determined　by　clustering,　finally　the　cortical　muscle　functional　connection　is　obtained　by　using　partial　transfer　entropy.　The　functional　connectivity　of　ICsF　with　AD,　ICsB　with　BIC,　ICsC　with　PD,　PM,　and　UT　in　the　upstream　channels　was　significantly　enhanced　in　stroke　patients　compared　with　healthy　controls　(For　example,　the　healthy　control　group　is　0.033　+　0.031,　the　stroke　patiënt　is　0.092　±0.083,　P＜0.　05).　The　functional　connectivity　of　BIC　with　ICsA,　ICsB　and　ICsC,　TRI　and　UT　with　ICsC　in　the　downstream　channels　was　signifieantly　enhanced　in　stroke　patients　eompared　with　healthy　controls　(For　example,　the　healthy　control　group　is　0.　113　±0.092,　and　the　stroke　patients　are　0.　198　+　0.　105,　P＜0.　05).　Ipsilateral　cortical　muscle　functional　connectivity　is　present　in　stroke　patients.　The　experimental　results　show　that　this　paper　explores　the　cortical　muscle　functional　connection　effect　after　stroke　from　a　new　angle,　and　proves　that　there　exists　ipsilateral　cortical　muscle　functional　connection　in　stroke　patients,　which　further　effectively　promotes　the　understanding　of　neuromuscular　coupling　mechanism　after　stroke.　©　2024　Chinese　Academy　of　Medical　Sciences.　All　rights　reserved.