To　solve　the　problem　of　the　filling　bodies　failure　on　both　sides　of　the　room　caused　by　differential　blasting　of　large　diameter　deep　holes　in　underground　mine,　the　stress　field　generated　by　differential　blasting　should　be　studied　to　determine　a　reasonable　edge　hole　spacing　and　a　delay　time　between　the　holes.　According　to　the　stress　wave　propagation　and　attenuation　law,　the　front　and　rear　detonation　hole　distance,　delay　time,　and　edge　hole　distance　generated　by　complex　stress　field　were　determined.　Furthermore,　the　superposition　of　the　stress　wave　generated　by　the　two-hole　differential　blasting　in　the　blasted　rock　mass　and　the　filling　body　was　analyzed　according　to　the　wave　theory.　The　stress　field　function　analytical　formula　of　the　two-hole　differential　blasting　was　obtained.　Meanwhile,　the　collapse　range　of　the　blasted　rock　mass　and　the　failure　range　of　the　filled　body　under　different　side　hole　spacing　conditions　under　the　same　hole　spacing　and　delay　time　were　determined.　The　LS-DYNA　numerical　simulation　software　established　six　numerical　models,　and　the　stress　critical　points　were　selected　in　the　blasted　rock　mass　and　filling　body　for　analysis　after　simulating　the　initiation　of　explosives　under　different　schemes.　The　simulation　results　show　that　different　edge　hole　distances　had　almost　no　effect　on　the　collapse　range　of　the　exposed　rock　mass　when　the　distance　between　edge　holes　was　more　significant　than　the　range　of　the　crack　zone.　Appropriately　increasing　the　distance　between　edge　holes　can　effectively　reduce　the　damage　caused　by　stress　waves　to　the　filling　body.　Finally,　the　field　industrial　test　of　four　groups　of　blasting　parameters　was　carried　out,　and　the　optimized　blasting　parameters　were　determined　as　the　spacing　between　the　two　holes　on　the　same　side　was　2.　0　m,　the　delay　time　between　the　front　and　rear　initiation　holes　was　9　ms,　and　the　side　hole　spacing　was　1.8m.　©　2024　BLASTING　Magazine　Editorial　Office,　Wuhan　University　of　Technology.　All　rights　reserved.