Glycosyl　sulfonamides　have　been　identified　as　novel　inhibitors　of　carbonic　anhydrase,　showing　great　potential　for　cancer　treatment.　However,　previous　approaches　to　synthesizing　glycosyl　sulfonamides　require　multi　steps,　resulting　in　low　efficiency　and　being　time-consuming.　Herein,　we　disclose　a　reductive　coupling　strategy　that　enables　the　modular　synthesis　of　glycosyl　sulfonamide　using　readily　accessible　glycosyl　sulfinates　and　feedstock　chemical　nitroarenes.　This　method　allows　for　the　construction　of　rarely　reported　N-aryl　glycosyl　sulfonamides　and　exhibits　tolerance　to　a　variety　of　functional　groups.