The　rise　of　antibiotic　resistance　and　the　formation　of　biofilms　by　certain　clinical　pathogens　pose　severe　challenges　for　patients　with　chronic　and　non-healing　wounds.　To　mitigate　the　overuse　of　antibiotics　and　reduce　the　incidence　of　multi　drug-resistant　Organism　(MDRO)　infection,　researchers　have　developed　a　metal-loaded　nanomaterial　as　an　alternative　to　traditional　treatments.　In　this　study,　Fe-Ga　doped　mesoporous　silicon　nanomaterials　(Fe-Ga@SiO2)　for　MDRO　infection　treatment　and　wound　healing.　This　material　induces　various　physiological　reactions,　including　the　production　of　reactive　oxygen　species　(ROS)　and　the　attachment　and　breakdown　of　bacteria　during　wound　healing.　Additionally,　Fe-Ga@SiO2　decreases　bacterial　growth　on　mouse　skin,　promotes　collagen　deposition,　and　accelerates　the　healing　of　bacterial　infections.　Our　research　offers　a　straightforward　yet　effective　approach　for　designing　nanometal　particles　for　antimicrobial　therapy,　spraying　the　material　on　the　infected　wounds　inhibits　bacterial　growth,　effectively　alleviates　wound　sensation,　and　promotes　healing　within　two　weeks.　©　2025　Elsevier　B.V.