Organic　micropollutants　in　wastewater　containing　arsanilic　acid　(p-ASA)　can　undergo　a　transformation　into　a　highly　toxic　inorganic　arsenic,　impacting　both　the　environment　and　human　health.　Adsorption　materials　such　as　Metal-organic　frameworks　(MOFs)　have　attracted　great　interest,　yet　their　production　methods　are　often　complex,　costly,　and　time-consuming,　hindering　large-scale　production.　We　introduces　an　innovative,　high-throughput　microfluidic　magnifiable　manufacturing　approach　to　expedite　MOFs　creation,　enabling　rapid,　continuous,　and　parallel　expandable　scalable　production　of　MOFs　with　a　uniform　microstructure　in　mere　minutes,　significantly　outpacing　the　traditional,　intermittently　operated　hydrothermal　synthesis.　The　microfluidic-generated　microstructured　MF-UIO-66　has　better　organic　arsenic　adsorption　capacity　(333.3　mg/g),　and　maintained　an　89.2　%　effectiveness　even　after　four　cycles　of　reuse　without　generating　harmful　by-products.　When　compared　to　UIO-66　produced　via　conventional　hydrothermal　methods,　the　microfluidically　synthesized　MF-UIO-66　showcases　not　only　a　faster　and　more　effective　removal　of　varying　concentrations　of　organic　arsenic　but　also　enhanced　chemical　stability　and　longevity.　The　novel　microfluidic　fabrication　strategy　holds　great　potential　for　the　industrial-scale　production　of　MF-UIO-66　at　reduced　costs　and　increased　yields.　©　2025　Elsevier　B.V.