Selenium enrichment enhances the alleviating effect of Lactobacillus rhamnosus GG on alcoholic liver injury in mice - Details

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Abstract：

Selenium-enriched　probiotics　have　attracted　much　attention　due　to　the　physiological　activities　of　both　probiotics　and　selenium　(organic　selenium).　In　this　study,　we　investigated　the　mitigating　effect　of　selenium-enriched　Lactobacillus　rhamnosus　GG　(LGG@Se)　and　its　pathway　on　alcohol-induced　liver　injury　(ALI)　in　mice.　The　results　showed　that　LGG@Se　was　superior　to　LGG　and　sodium　selenite　in　alleviating　ALI.　Oral　LGG@Se　effectively　prevented　lipid　metabolism　disorders　and　liver　oxidative　damage　in　mice　caused　by　excessive　alcohol　intake.　16S　amplicon　sequencing　showed　that　LGG@Se　intervention　increased　the　abundance　of　beneficial　bacteria　and　suppressed　the　growth　of　harmful　bacteria　in　the　intestinal　tract　of　over-drinking　mice,　and　thus　effectively　modulated　the　homeostasis　of　intestinal　flora,　which　were　highly　correlated　with　the　improvement　of　liver　function.　Liver　metabolomics　analysis　indicated　that　LGG@Se　intervention　altered　liver　metabolic　profiling,　and　the　characteristic　biomarkers　were　mainly　involved　in　amino　acid　metabolism,　including　alanine,　aspartate　and　glutamate　metabolism,　arginine　biosynthesis,　etc.　In　addition,　LGG@Se　intervention　modulated　the　expression　of　genes　and　proteins　related　to　lipid　metabolism　and　oxidative　stress　in　liver　of　over-drinking　mice.　Western　blot　analysis　revealed　that　LGG@Se　intervention　up-regulated　the　expression　of　intestinal　barrier　function-related　proteins,　thereby　ameliorating　alcohol-induced　intestinal　barrier　damage.　Collectively,　these　findings　provide　scientific　evidence　that　LGG@Se　possesses　the　biological　activity　of　improving　alcohol-induced　lipid　metabolism　and　intestinal　microbiota　disorder.　©　2024　The　Authors

Keyword：

Alcoholic liver injury Intestinal microbiota Lactobacillus rhamnosus GG Liver metabolomics Selenium-enriched probiotics

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[ 1 ] [Yang Z.]Institute of Food Science and Technology, College of Biological Science and Engineering, Fuzhou University, Fujian, Fuzhou, 350108, China
[ 2 ] [Yang Z.]Food Nutrition and Health Research Center, School of Advanced Manufacturing, Fuzhou University, Fujian, Jinjiang, 362200, China
[ 3 ] [Lian J.]Institute of Food Science and Technology, College of Biological Science and Engineering, Fuzhou University, Fujian, Fuzhou, 350108, China
[ 4 ] [Lian J.]College of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China
[ 5 ] [Yang Y.]Department of Hepatopancreatobiliary Surgery, Fujian Research Institute of Abdominal Surgery, The First Affiliated Hospital of Fujian Medical University, Fujian, Fuzhou, 350005, China
[ 6 ] [Li J.]Institute of Food Science and Technology, College of Biological Science and Engineering, Fuzhou University, Fujian, Fuzhou, 350108, China
[ 7 ] [Li J.]Food Nutrition and Health Research Center, School of Advanced Manufacturing, Fuzhou University, Fujian, Jinjiang, 362200, China
[ 8 ] [Guo W.]Institute of Food Science and Technology, College of Biological Science and Engineering, Fuzhou University, Fujian, Fuzhou, 350108, China
[ 9 ] [Guo W.]Food Nutrition and Health Research Center, School of Advanced Manufacturing, Fuzhou University, Fujian, Jinjiang, 362200, China
[ 10 ] [Lv X.]Institute of Food Science and Technology, College of Biological Science and Engineering, Fuzhou University, Fujian, Fuzhou, 350108, China
[ 11 ] [Lv X.]Food Nutrition and Health Research Center, School of Advanced Manufacturing, Fuzhou University, Fujian, Jinjiang, 362200, China
[ 12 ] [Ni L.]Institute of Food Science and Technology, College of Biological Science and Engineering, Fuzhou University, Fujian, Fuzhou, 350108, China
[ 13 ] [Ni L.]Food Nutrition and Health Research Center, School of Advanced Manufacturing, Fuzhou University, Fujian, Jinjiang, 362200, China
[ 14 ] [Chen Y.]Department of Hepatopancreatobiliary Surgery, Fujian Research Institute of Abdominal Surgery, The First Affiliated Hospital of Fujian Medical University, Fujian, Fuzhou, 350005, China

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Current Research in Food Science

ISSN： 2665-9271

Year： 2025

Volume： 10

6 . 2 0 0

JCR@2023

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ESI Highly Cited Papers on the List： 0 Unfold All

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30 Days PV： 1

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