A　traditional　hybrid　operational　mode　of　a　metro　system　usually　combines　the　express　and　local　trains.　The　stopping　patterns　of　express　trains　are　generally　assumed　to　be　the　same.　To　provide　a　diverse　service,　this　paper　aims　to　explore　the　train　timetable　optimization　method　when　the　express　trains　have　different　stopping　patterns.　First,　all　the　trains　are　categorized　into　five　cases　based　on　the　type　of　train　and　the　order　of　departure.　A　passenger-oriented　timetabling　model　for　reducing　passenger　waiting　time　is　established,　which　can　be　solved　by　the　Interior　Point　Method.　Numerical　examples　from　Guangzhou　Metro　Network　are　conducted　with　six　scenarios,　symbolizing　different　operation　strategies.　The　proposed　model　was　validated　through　numerical　experiments　conducted　on　a　Nanjing　metro　line.　The　results　indicate　that　the　proposed　model　can　efficiently　reschedule　the　timetable　in　express/local　mode　with　multiple　stopping　patterns　and　reduce　the　passenger　waiting　time,　the　most　considerable　reduction　of　which　comes　up　to　16.8%,　along　with　a　reduction　in　their　extra　waiting　time　of　up　to　17.3%.